Title:
A METHOD OF DETERMINING A PREDISPOSITION TO ATRIAL FIBRILLATION IN A SUBJECT
Document Type and Number:
WIPO Patent Application WO/2012/000119
Kind Code:
A8
Abstract:
The present invention concerns a method of determining a predisposition to atrial fibrillation (AF) in a subject comprising: determining the presence of at least one copy of a risk allele from at least one polymorphic marker in a sample from the subject, wherein the presence of at least one copy of the risk allele is indicative of a predisposition to AF, and wherein said at least one polymorphic marker is :a) rs4674485; b) rs1466560; c) rs1880039; d) rs3849387; e) rs7039; f) rs2952860; g) rs9312515; h) rs1897527; i) rs2299277; j) rs2418828; k) rs2385833; I) rs6717960; m) rs10510266; or n) a substitute polymorphic marker in linkage disequilibrium with any one of the polymorphic markers of a) to m). Also described are kits for determining a predisposition to atrial fibrillation (AF) and uses therefore.
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Inventors:
HAMET PAVEL (CA)
TREMBLAY JOHANNE (CA)
DE CHAMPLAIN JACQUES (CA)
NADEAU REGINALD (CA)
LAROCHELLE PIERRE (CA)
CHALMERS JOHN (AU)
MACMAHON STEPHEN (AU)
TREMBLAY JOHANNE (CA)
DE CHAMPLAIN JACQUES (CA)
NADEAU REGINALD (CA)
LAROCHELLE PIERRE (CA)
CHALMERS JOHN (AU)
MACMAHON STEPHEN (AU)
Application Number:
PCT/CA2011/050409
Publication Date:
March 15, 2012
Filing Date:
July 04, 2011
Export Citation:
Assignee:
PROGNOMIX INC (CA)
HAMET PAVEL (CA)
TREMBLAY JOHANNE (CA)
DE CHAMPLAIN JACQUES (CA)
NADEAU REGINALD (CA)
LAROCHELLE PIERRE (CA)
CHALMERS JOHN (AU)
MACMAHON STEPHEN (AU)
HAMET PAVEL (CA)
TREMBLAY JOHANNE (CA)
DE CHAMPLAIN JACQUES (CA)
NADEAU REGINALD (CA)
LAROCHELLE PIERRE (CA)
CHALMERS JOHN (AU)
MACMAHON STEPHEN (AU)
International Classes:
C12Q1/68; C40B30/00; G01N33/68
Attorney, Agent or Firm:
GOUDREAU GAGE DUBUC (Suite 2200Montréal, Québec H3A 3H3, CA)
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