Title:
METHOD FOR DETERMINING PRESENCE OR ABSENCE OF CARIES OR RISK OF DEVELOPMENT THEREOF, AND BIOMARKER
Document Type and Number:
WIPO Patent Application WO/2019/004400
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a method for easily determining the presence or absence of caries or the risk of caries, irrespective of the existence of caries experience, and is a method for measuring the amount or abundance ratio of marker bacteria to total bacteria in a biological sample collected from a subject in order to determine the subject's risk of caries, wherein the marker bacteria are at least one type selected from the group consisting of bacteria of the genus Campylobacter, bacteria of the genus Veillonella, bacteria of the genus Treponema, bacteria of the genus Neisseria, bacteria of the genus Moraxella, bacteria of the genus Granulicatella, bacteria of the genus Alloprevotella, bacteria of the genus Dialister, bacteria of the genus Tannerella, bacteria of the genus Lachnoanaerobaculum, and bacteria of the genus Megasphaera.
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Inventors:
MARUYAMA MASATO (JP)
Application Number:
PCT/JP2018/024721
Publication Date:
January 03, 2019
Filing Date:
June 28, 2018
Export Citation:
Assignee:
LION CORP (JP)
International Classes:
C12Q1/06; C12Q1/6851; C12Q1/689; G01N33/50
Domestic Patent References:
| WO2018012011A1 | 2018-01-18 | |||
| WO2013046995A1 | 2013-04-04 |
Foreign References:
| JP2017023093A | 2017-02-02 | |||
| JP2014023434A | 2014-02-06 | |||
| JP2016214101A | 2016-12-22 | |||
| JP2015039361A | 2015-03-02 | |||
| JP2011234687A | 2011-11-24 |
Other References:
WANG, Y. ET AL.: "Profiling of oral microbiota in early childhood caries using single-molecule real- time sequencing.", FRONTIERS IN MICROBIOLOGY, vol. 8, 15 November 2017 (2017-11-15), pages 1 - 15, XP055562739
JIANG, S. ET AL.: "Salivary microbiome diversity in caries-free and caries-affected children", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 17, no. 12, 25 November 2016 (2016-11-25), pages 1 - 13, XP055562742
HART, T. C. ET AL.: "Identification of microbial and proteomic biomarkers in early childhood caries.", INTERNATIONAL JOURNAL OF DENTISTRY, vol. 2011, 16 October 2011 (2011-10-16), pages 1 - 13, XP055562743
JIANG, W. ET AL.: "Pyrosequencing analysis of oral micrbiota shifting in various caries states in childhood.", MICROBIAL ECOLOGY, vol. 67, no. 4, May 2014 (2014-05-01), pages 962 - 969, XP055562745
DOWNES, J. ET AL.: "Description of Alloprevotella rava gen. nov., sp. nov., isolated from the human oral cavity, and reclassification of Prevotella tannerae Moore et al. 1994 as Alloprevotella tannerae gen. nov., comb. nov.", INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, vol. 63, 2013, pages 1214 - 1218, XP055562746
JIANG, S. ET AL.: "Salivary microbiome diversity in caries-free and caries-affected children", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 17, no. 12, 25 November 2016 (2016-11-25), pages 1 - 13, XP055562742
HART, T. C. ET AL.: "Identification of microbial and proteomic biomarkers in early childhood caries.", INTERNATIONAL JOURNAL OF DENTISTRY, vol. 2011, 16 October 2011 (2011-10-16), pages 1 - 13, XP055562743
JIANG, W. ET AL.: "Pyrosequencing analysis of oral micrbiota shifting in various caries states in childhood.", MICROBIAL ECOLOGY, vol. 67, no. 4, May 2014 (2014-05-01), pages 962 - 969, XP055562745
DOWNES, J. ET AL.: "Description of Alloprevotella rava gen. nov., sp. nov., isolated from the human oral cavity, and reclassification of Prevotella tannerae Moore et al. 1994 as Alloprevotella tannerae gen. nov., comb. nov.", INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, vol. 63, 2013, pages 1214 - 1218, XP055562746
Attorney, Agent or Firm:
SAKAI INTERNATIONAL PATENT OFFICE (JP)
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