Title:
METHOD FOR DETERMINING PROGNOSIS OF CANCER
Document Type and Number:
WIPO Patent Application WO/2020/059850
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a method for determining a prognosis or a method for assisting in determining a prognosis of hormone-receptor-positive cancer (e.g., ER-α-positive breast cancer, ER-α-positive endometrial cancer, etc.), and a method for evaluating susceptibility to antihormone therapy or a method for assisting in evaluating susceptibility to antihormone therapy. Specifically, the present invention is a method for determining a prognosis or a method for assisting in determining a prognosis of hormone-receptor-positive cancer, including steps (a) and (b). (a): A step for detecting Fbxo22-positive cells in a sample originating from cancer tissue. (b): A step for calculating the ratio of Fbxo22-positive cells with respect to the cells present in the sample.
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Inventors:
NAKANISHI MAKOTO (JP)
JOHMURA YOSHIKAZU (JP)
OHTA TOMOHIKO (JP)
JOHMURA YOSHIKAZU (JP)
OHTA TOMOHIKO (JP)
Application Number:
PCT/JP2019/036949
Publication Date:
March 26, 2020
Filing Date:
September 20, 2019
Export Citation:
Assignee:
UNIV TOKYO (JP)
UNIV SCHOOL ST MARIANNA MEDICINE (JP)
UNIV SCHOOL ST MARIANNA MEDICINE (JP)
International Classes:
G01N33/574; C12Q1/06; G01N33/53; A61K31/085; A61K31/138; A61K31/167; A61K31/277; A61K31/40; A61K31/4535; A61K45/00; A61P35/00
Domestic Patent References:
| WO2017108345A1 | 2017-06-29 | |||
| WO2006035975A1 | 2006-04-06 | |||
| WO2016115572A1 | 2016-07-21 |
Foreign References:
| JP2016214245A | 2016-12-22 | |||
| JP2011223957A | 2011-11-10 |
Other References:
JOHMURA, YOSHIKAZU ET AL.: "Fbxo22-mediated KDM4B degradation determines selective estrogen receptor modulator activity in breast cancer", J CLIN INVEST, vol. 128, no. 12, 3 December 2018 (2018-12-03), pages 5603 - 5619, XP055694061, [retrieved on 20181112]
BAI, JIN ET AL.: "SCFFBxo22 targets HDM2 for degradation and modulates breast cancer cell invasion and metastasis", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 116, no. 24, 11 June 2019 (2019-06-11), pages 11754 - 11763, XP055694063, [retrieved on 20190528]
BAI, JIN ET AL.: "SCFFBxo22 targets HDM2 for degradation and modulates breast cancer cell invasion and metastasis", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 116, no. 24, 11 June 2019 (2019-06-11), pages 11754 - 11763, XP055694063, [retrieved on 20190528]
Attorney, Agent or Firm:
OKUHARA Koji et al. (JP)
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