Title:
METHOD OF DETERMINING RESISTANCE TO INFLUENZA VIRUS
Document Type and Number:
WIPO Patent Application WO/2015/025825
Kind Code:
A1
Abstract:
Provided is a method of providing an effective means as a countermeasure for handling a pandemic of an influenza virus. The resistance to a type-A influenza virus is determined using, as an indicator, the presence or otherwise of antibodies using the VH1-69 gene in a biological sample originating from a subject.
Inventors:
KUROSAWA YOSHIKAZU (JP)
OHSHIMA NOBUKO (JP)
OHSHIMA NOBUKO (JP)
Application Number:
PCT/JP2014/071591
Publication Date:
February 26, 2015
Filing Date:
August 18, 2014
Export Citation:
Assignee:
UNIV FUJITA HEALTH (JP)
International Classes:
G01N33/53; G01N33/569
Domestic Patent References:
| WO2012029997A1 | 2012-03-08 |
Foreign References:
| JP2010502207A | 2010-01-28 |
Other References:
NOBUKO OHSHIMA ET AL.: "Naturally Occurring Antibodies in Humans Can Neutralize a Variety of Influenza Virus Strains, Including H3, H1, H2, and H5", J. VIROL., vol. 85, no. 21, August 2011 (2011-08-01), pages 11048 - 11057, XP055014225
DANIEL LINGWOOD ET AL.: "Structural and genetic basis for development of broadly neutralizing influenza antibodies", NATURE, vol. 489, no. 7417, 27 September 2012 (2012-09-27), pages 566 - 570, XP055087997
OKADA, J. ET AL.: "Monoclonal antibodies in man that neutralized H3N2 influenza viruses were classified in to three groups with distinct strain specificity", VIROLOGY, vol. 397, no. 2, 1968, pages 322 - 330 D 1997-2003, XP026888068
TAIA T. WANG ET AL.: "Universal epitopes of influenza virus hemagglutinins?", NATURE STRUCTURAL & MOLECULAR BIOLOGY, vol. 16, no. 3, March 2009 (2009-03-01), pages 233 - 234, XP009137026
JIANHUA SUI ET AL.: "Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses", NAT. STRUC. MOL. BIOL., vol. 16, 2009, pages 265 - 273, XP002538005
KYOSUKE NAGATA: "Analysis of the Cellular Gene Product that Confers Resistance to the Virus Infection", THE ASAHI GLASS FOUNDATION JOSEI KENKYU SEIKA HOKOKU, vol. 1995, December 1995 (1995-12-01), pages 283 - 290, XP008182891
See also references of EP 3037819A4
SKEHEL, J.J.; WILEY, D.C.: "Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin", ANN. REV. BIOCHEM., vol. 69, 2000, pages 531 - 569
KNOSSOW, M. ET AL.: "Mechanism of neutralization of onfluenza virus infectivity by antibodies", VIROLOGY, vol. 302, 2002, pages 294 - 298
OKUNO, Y.; ISEGAWA, Y.; SASAO, F.; UEDA, S. A: "common neutralizing epitope conserved between the hemagglutinins of influenza A virus HI and H2 strains", J. VIROL., vol. 67, 1993, pages 2552 - 2558
FRASER, C. ET AL.: "Pandemic potential of a strain of influenza A (H1N1): early findings", SCIENCE, vol. 324, 2009, pages 1557 - 1561
HANCOCK, K. ET AL.: "Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus", N. ENGL. J. MED., vol. 361, 2009, pages 1945 - 1952
WRAMMERT, J. ET AL.: "Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection", J. EXP. MED., vol. 208, 2011, pages 181 - 193
LI, G.M. ET AL.: "Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells", PROC. NATL. ACAD. SCI., vol. 109, 2012, pages 9047 - 9052
OKUNO, Y.; ISEGAWA, Y.; SASAO, F.; UEDA, S.: "A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains", J. VIROL., vol. 67, 1993, pages 2552 - 2558
HANCOCK, K. ET AL.: "Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus", N. ENGL.. . MED., vol. 361, 2009, pages 1945 - 1952
OKADA, J. ET AL.: "Monoclonal antibodies in man that neutralized H3N2 influenza viruses were classified in to three groups with distinct strain specificity: 1968-1973, 1977-1993 and 1997-2003", VIROLOGY, vol. 397, 2010, pages 322 - 330
OKUNO, Y. ET AL.: "Rapid focus reduction neutralization test of influenza A and B viruses in microtiter system", J. CLIN. MICROBIOL., vol. 28, 1990, pages 1308 - 13131
OHSHIMA, N. ET AL.: "Naturally occurring antibodies in humans can neutralize a variety of influenza viral strains, including H3, H1, H2, and H5", J. VIROL., vol. 85, 2011, pages 11048 - 11057
ITO, W.; KUROSAWA, Y.: "Development of an artificial antibody system with multiple valency using an Fv fragment fused to a fragment of protein A", J. BIOL. CHEM., vol. 268, 1993, pages 20668 - 20675
SUI, J. ET AL.: "Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses", NAT. STRUC. MOL. BIOL., vol. 16, 2009, pages 265 - 273
EKIERT, D.C. ET AL.: "Antibody recognition of a highly conserved influenza virus epitope", SCIENCE, vol. 324, 2009, pages 246 - 251
OKADA, J. ET AL.: "Localization of epitopes recognized by monoclonal antibodies that neutralized the H3N2 influenza viruses in man", J. GEN. VIROL., vol. 92, 2011, pages 326 - 335
DANIEL LINGWOOD ET AL.: "Structural and genetic basis for development of broadly neutralizing influenza antibodies", NATURE, vol. 489, no. 7417, 27 September 2012 (2012-09-27), pages 566 - 570, XP055087997
OKADA, J. ET AL.: "Monoclonal antibodies in man that neutralized H3N2 influenza viruses were classified in to three groups with distinct strain specificity", VIROLOGY, vol. 397, no. 2, 1968, pages 322 - 330 D 1997-2003, XP026888068
TAIA T. WANG ET AL.: "Universal epitopes of influenza virus hemagglutinins?", NATURE STRUCTURAL & MOLECULAR BIOLOGY, vol. 16, no. 3, March 2009 (2009-03-01), pages 233 - 234, XP009137026
JIANHUA SUI ET AL.: "Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses", NAT. STRUC. MOL. BIOL., vol. 16, 2009, pages 265 - 273, XP002538005
KYOSUKE NAGATA: "Analysis of the Cellular Gene Product that Confers Resistance to the Virus Infection", THE ASAHI GLASS FOUNDATION JOSEI KENKYU SEIKA HOKOKU, vol. 1995, December 1995 (1995-12-01), pages 283 - 290, XP008182891
See also references of EP 3037819A4
SKEHEL, J.J.; WILEY, D.C.: "Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin", ANN. REV. BIOCHEM., vol. 69, 2000, pages 531 - 569
KNOSSOW, M. ET AL.: "Mechanism of neutralization of onfluenza virus infectivity by antibodies", VIROLOGY, vol. 302, 2002, pages 294 - 298
OKUNO, Y.; ISEGAWA, Y.; SASAO, F.; UEDA, S. A: "common neutralizing epitope conserved between the hemagglutinins of influenza A virus HI and H2 strains", J. VIROL., vol. 67, 1993, pages 2552 - 2558
FRASER, C. ET AL.: "Pandemic potential of a strain of influenza A (H1N1): early findings", SCIENCE, vol. 324, 2009, pages 1557 - 1561
HANCOCK, K. ET AL.: "Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus", N. ENGL. J. MED., vol. 361, 2009, pages 1945 - 1952
WRAMMERT, J. ET AL.: "Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection", J. EXP. MED., vol. 208, 2011, pages 181 - 193
LI, G.M. ET AL.: "Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells", PROC. NATL. ACAD. SCI., vol. 109, 2012, pages 9047 - 9052
OKUNO, Y.; ISEGAWA, Y.; SASAO, F.; UEDA, S.: "A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains", J. VIROL., vol. 67, 1993, pages 2552 - 2558
HANCOCK, K. ET AL.: "Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus", N. ENGL.. . MED., vol. 361, 2009, pages 1945 - 1952
OKADA, J. ET AL.: "Monoclonal antibodies in man that neutralized H3N2 influenza viruses were classified in to three groups with distinct strain specificity: 1968-1973, 1977-1993 and 1997-2003", VIROLOGY, vol. 397, 2010, pages 322 - 330
OKUNO, Y. ET AL.: "Rapid focus reduction neutralization test of influenza A and B viruses in microtiter system", J. CLIN. MICROBIOL., vol. 28, 1990, pages 1308 - 13131
OHSHIMA, N. ET AL.: "Naturally occurring antibodies in humans can neutralize a variety of influenza viral strains, including H3, H1, H2, and H5", J. VIROL., vol. 85, 2011, pages 11048 - 11057
ITO, W.; KUROSAWA, Y.: "Development of an artificial antibody system with multiple valency using an Fv fragment fused to a fragment of protein A", J. BIOL. CHEM., vol. 268, 1993, pages 20668 - 20675
SUI, J. ET AL.: "Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses", NAT. STRUC. MOL. BIOL., vol. 16, 2009, pages 265 - 273
EKIERT, D.C. ET AL.: "Antibody recognition of a highly conserved influenza virus epitope", SCIENCE, vol. 324, 2009, pages 246 - 251
OKADA, J. ET AL.: "Localization of epitopes recognized by monoclonal antibodies that neutralized the H3N2 influenza viruses in man", J. GEN. VIROL., vol. 92, 2011, pages 326 - 335
Attorney, Agent or Firm:
HAGINO Mikiharu (JP)
Kanji Hagino (JP)
Kanji Hagino (JP)
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