Title:
METHOD FOR DETERMINING SUSCEPTIBILITY TO AGE-RELATED MACULAR DEGENERATION, PRIMER PAIR, PROBE, AGE-RELATED MACULAR DEGENERATION DIAGNOSTIC KIT, THERAPEUTIC AGENT FOR AGE-RELATED MACULAR DEGENERATION, AND SCREENING METHOD FOR THERAPEUTIC AGENT FOR AGE-RELATED MACULAR DEGENERATION
Document Type and Number:
WIPO Patent Application WO/2013/035861
Kind Code:
A1
Abstract:
A method for determining susceptibility to age-related macular degeneration comprising a step for determining the type of the 238th base from the 5'-end to the 3'-end of the LOC389641 gene contained in a sample from a subject. If the type of the aforementioned base is determined to be thymine in the aforementioned step, the subject is determined to be susceptible to age-related macular degeneration, and if the type of the base is determined to be guanine in the step, the subject is determined not to be susceptible to age-related macular degeneration.
Inventors:
ISHIBASHI TATSURO (JP)
KUBO MICHIAKI (JP)
ARAKAWA SATOSHI (JP)
KUBO MICHIAKI (JP)
ARAKAWA SATOSHI (JP)
Application Number:
PCT/JP2012/072974
Publication Date:
March 14, 2013
Filing Date:
September 07, 2012
Export Citation:
Assignee:
UNIV KYUSHU NAT UNIV CORP (JP)
RIKEN (JP)
NIPPON MEDICAL SCHOOL FOUNDATION (JP)
UNIV NIHON (JP)
IWATE MEDICAL UNIVERSITY (JP)
TOKUSHUKAI (JP)
ISHIBASHI TATSURO (JP)
KUBO MICHIAKI (JP)
ARAKAWA SATOSHI (JP)
RIKEN (JP)
NIPPON MEDICAL SCHOOL FOUNDATION (JP)
UNIV NIHON (JP)
IWATE MEDICAL UNIVERSITY (JP)
TOKUSHUKAI (JP)
ISHIBASHI TATSURO (JP)
KUBO MICHIAKI (JP)
ARAKAWA SATOSHI (JP)
International Classes:
C12Q1/68; A61K45/00; A61K48/00; A61P27/02; C12N15/09; C12Q1/02; G01N33/15; G01N33/50
Domestic Patent References:
| WO2012082912A2 | 2012-06-21 |
Foreign References:
| JP2009027972A | 2009-02-12 |
Other References:
KUNIKO INOUE (HORIE) ET AL.: "Morateki Idenshi Tagata Kaiseki to Genome Joho ni Motozuku Karei Ohan Hensei Gen'in Idenshi no Kaimei to Kino Kaiseki", JOURNAL OF SAITAMA MEDICAL UNIVERSITY, vol. 35, no. 1, 2008, pages 42 - 45
KUNIKO HORIE: "AMD no Risk Factor", PHARMA MEDICA, vol. 28, no. 12, 2010, pages 27 - 31
KLEIN R. J. ET AL.: "Complement Factor H Polymorphism in Age-Related Macular Degeneration", SCIENCE, vol. 308, 2005, pages 385 - 389
RIVERA A. ET AL.: "Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk", HUMAN MOLECULAR GENETICS, vol. 14, no. 21, 2005, pages 3227 - 3236
GUAN B. ET AL.: "Evidence that the human death receptor 4 is regulated by activator protein 1", ONCOGENE, vol. 21, 2002, pages 3121 - 3129
ARAKAWA S. ET AL.: "Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population", NATURE GENETICS, vol. 43, no. 10, 11 September 2011 (2011-09-11), pages 1001 - 1004
SATOSHI ARAKAWA ET AL.: "17. Genome-wide Kanren Kaiseki ni yoru Nipponjin deno Shinshutsugata Karei Ohan Hensei no Kanjusei Idenshi o Dotei", MOMAKU MYAKURAKUMAKU ? SHISHINKEI ISHUKUSHO NI KANSURU CHOSA KENKYU HEISEI 23 NENDO SOKATSU - BUNTAN KENKYU HOKOKUSHO, March 2012 (2012-03-01), pages 60 - 62
KUNIKO HORIE: "AMD no Risk Factor", PHARMA MEDICA, vol. 28, no. 12, 2010, pages 27 - 31
KLEIN R. J. ET AL.: "Complement Factor H Polymorphism in Age-Related Macular Degeneration", SCIENCE, vol. 308, 2005, pages 385 - 389
RIVERA A. ET AL.: "Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk", HUMAN MOLECULAR GENETICS, vol. 14, no. 21, 2005, pages 3227 - 3236
GUAN B. ET AL.: "Evidence that the human death receptor 4 is regulated by activator protein 1", ONCOGENE, vol. 21, 2002, pages 3121 - 3129
ARAKAWA S. ET AL.: "Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population", NATURE GENETICS, vol. 43, no. 10, 11 September 2011 (2011-09-11), pages 1001 - 1004
SATOSHI ARAKAWA ET AL.: "17. Genome-wide Kanren Kaiseki ni yoru Nipponjin deno Shinshutsugata Karei Ohan Hensei no Kanjusei Idenshi o Dotei", MOMAKU MYAKURAKUMAKU ? SHISHINKEI ISHUKUSHO NI KANSURU CHOSA KENKYU HEISEI 23 NENDO SOKATSU - BUNTAN KENKYU HOKOKUSHO, March 2012 (2012-03-01), pages 60 - 62
Attorney, Agent or Firm:
KIMURA, MITSURU (JP)
Mitsuru Kimura (JP)
Mitsuru Kimura (JP)
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