METHOD OF DEUTERIZATION - WAKO PURE CHEM IND LTD

Title:

METHOD OF DEUTERIZATION

Document Type and Number:

WIPO Patent Application WO/2004/060831

Kind Code:

A1

Abstract:

A method of deuterizing a compound represented by the general formula [1]: R¹-X-R² [1] (wherein R¹ represents alkyl, etc.; R² represents alkyl, hydroxy, etc.; and X represents carbonyl or hydroxymethylene), which comprises reacting the compound represented by the general formula [1] with a deuterium source in the presence of a catalyst selected among activated palladium, platinum, rhodium, ruthenium, nickel, and cobalt catalysts. By the method, deuterization, which has been conducted under severe conditions, can be conducted under neutral conditions. Even when the compound contains an unsaturated bond, it can be deuterized without reducing the unsaturated bond.

Inventors:

ITO NOBUHIRO (JP)
MAESAWA TSUNEAKI (JP)
MUTO KAZUSHIGE (JP)
HIROTA KOSAKU (JP)
SAJIKI HIRONAO (JP)

Application Number:

PCT/JP2003/014182

Publication Date:

July 22, 2004

Filing Date:

November 07, 2003

Export Citation:

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Assignee:

WAKO PURE CHEM IND LTD (JP)
ITO NOBUHIRO (JP)
MAESAWA TSUNEAKI (JP)
MUTO KAZUSHIGE (JP)
HIROTA KOSAKU (JP)
SAJIKI HIRONAO (JP)

International Classes:

C07B59/00; C07C29/00; C07C45/00; (IPC1-7): C07B59/00; C07C29/00; C07C31/02; C07C35/08; C07C35/29; C07C35/37; C07C45/00; C07C49/04; C07C49/08; C07C49/433; C07C49/453; C07C51/00; C07C53/10; C07C53/124; C07C57/04

Foreign References:

JPS4517402B1	1970-06-16
JPS63198638A	1988-08-17
EP0203588A2	1986-12-03

Other References: