Title:
METHOD, DEVICE, COMPUTER PROGRAM AND COMPUTER-READABLE RECORDING MEDIUM FOR DESIGNING NUCLEIC ACID MOLECULES
Document Type and Number:
WIPO Patent Application WO/2021/112456
Kind Code:
A1
Abstract:
Disclosed is a method comprising the steps of: extracting the gene sequence of a first gene from a first database in response to reception of a user's input; generating segmented sequences on the basis of the reverse complementary sequence of the gene sequence of the first gene; identifying, on the basis of comparison of the segmented sequences with the gene sequences of a second database, at least one matching sequence corresponding to at least one segmented sequence of the segmented sequences, the at least one matching sequence targeting a second gene different from the first gene; identifying the sequence characteristics of the at least one segmented sequence and the at least one matching sequence; scoring the at least one segmented sequence and the at least one matching sequence by applying a first weight to a first sequence characteristic among the sequence characteristics and a second weight to a second sequence characteristic among the sequence characteristics, the second weight being larger than the first weight; and displaying the at least one segmented sequence and the at least one matching sequence on the basis of the scores of the at least one segmented sequence and the at least one matching sequence.
Inventors:
YOO JUNG-KI (KR)
CHOI CHUNG-GAB (KR)
UM KI-HWAN (KR)
LEE EUI-JIN (KR)
CHOI CHUNG-GAB (KR)
UM KI-HWAN (KR)
LEE EUI-JIN (KR)
Application Number:
PCT/KR2020/016318
Publication Date:
June 10, 2021
Filing Date:
November 19, 2020
Export Citation:
Assignee:
CURIGIN CO LTD (KR)
International Classes:
G16B35/10; G16B25/30; G16B30/10; G16B30/20; G16B50/00
Domestic Patent References:
| WO2019212238A1 | 2019-11-07 |
Foreign References:
| KR100707213B1 | 2007-04-13 |
Other References:
MAHMOUD ELHEFNAWI, NAFISA HASSAN, MONA KAMAR, RANIA SIAM, ANNA LISA REMOLI, IMAN EL-AZAB, OSAMA ALAIDY, GIULIA MARSILI, MARCO SGAR: "The design of optimal therapeutic small interfering RNA molecules targeting diverse strains of influenza A virus", BIOINFORMATICS, vol. 27, no. 24, 15 December 2011 (2011-12-15), pages 3364 - 3370, XP055817710, ISSN: 1367-4803, DOI: 10.1093/bioinformatics/btr555
NAITO YUKI, UI-TEI KUMIKO: "siRNA Design Software for a Target Gene-Specific RNA Interference", FRONTIERS IN GENETICS, vol. 3, 102, pages 1 - 7, XP055817712, DOI: 10.3389/fgene.2012.00102
E FAKHR, F ZARE , L TEIMOORI-TOOLABI: "Precise and efficient siRNA design: a key point in competent gene silencing", CANCER GENE THERAPY, vol. 23, no. 4, 18 March 2016 (2016-03-18), pages 73 - 82, XP037324995, ISSN: 0929-1903, DOI: 10.1038/cgt.2016.4
NAITO YUKI, UI-TEI KUMIKO: "siRNA Design Software for a Target Gene-Specific RNA Interference", FRONTIERS IN GENETICS, vol. 3, 102, pages 1 - 7, XP055817712, DOI: 10.3389/fgene.2012.00102
E FAKHR, F ZARE , L TEIMOORI-TOOLABI: "Precise and efficient siRNA design: a key point in competent gene silencing", CANCER GENE THERAPY, vol. 23, no. 4, 18 March 2016 (2016-03-18), pages 73 - 82, XP037324995, ISSN: 0929-1903, DOI: 10.1038/cgt.2016.4
Attorney, Agent or Firm:
WIE, Byoung-Gap (KR)
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