Title:
METHOD AND DEVICE FOR EXAMINING A CELL SAMPLE
Document Type and Number:
WIPO Patent Application WO/2014/122133
Kind Code:
A1
Abstract:
The invention relates to a method for examining a cell sample, wherein at least the steps of determining spatially resolved combinatorial binding patterns by means of a ligand library comprising at least two ligands in at least two cell elements of at least one cell of the cell sample and comparing the determined combinatorial binding patterns are performed. The invention further relates to a device (50) for performing such a method.
Inventors:
SCHUBERT WALTER (DE)
Application Number:
PCT/EP2014/052168
Publication Date:
August 14, 2014
Filing Date:
February 04, 2014
Export Citation:
Assignee:
TOPOSNOMOS LTD (DE)
International Classes:
G01N33/569
Other References:
SCHUBERT WALTER: "TOPOLOGICAL PROTEOMICS, TOPONOMICS, MELK-TECHNOLOGY", ADVANCES IN BIOCHEMICAL ENGINEERING, BIOTECHNOLOGY, SPRINGER, BERLIN, DE, vol. 83, 1 January 2003 (2003-01-01), pages 189 - 209, XP008079848, ISSN: 0724-6145
SCHUBERT WALTER ET AL: "Analyzing proteome topology and function by automated multidimensional fluorescence microscopy", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 24, no. 10, 1 October 2006 (2006-10-01), pages 1270 - 1278, XP002438060, ISSN: 1087-0156, DOI: 10.1038/NBT1250
BERNDT UTA ET AL: "Proteomic analysis of the inflamed intestinal mucosa reveals distinctive immune response profiles in Crohn's disease and ulcerative collitis", JOURNAL OF IMMUNOLOGY, vol. 179, no. 1, July 2007 (2007-07-01), pages 295 - 304, XP002721811, ISSN: 0022-1767
UTA BERNDT ET AL: "Systematic high-content proteomic analysis reveals substantial immunologic changes in colorectal cancer", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 68, no. 3, 1 February 2008 (2008-02-01), pages 880 - 888, XP002618323, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-07-2923
LEHMAN BROTHERS; MC KINSEY, THE FRUITS OF GENOMICS, 2001
HUTCHINSON L; KIRCK R: "High drug attrition rates - where are we going wrong?", NAT REV CLIN ONCOL, vol. 8, 2011, pages 189 - 190, XP055346417
WORLD ALZHEIMERS REPORT, 2011
MARCELLO MALPIGHI, PRINZIP DER HISTOLOGIE BESTIMMTEN WEG NÄMLICH, pages 1628 - 1694
SCHUBERT WALTER ET AL: "Analyzing proteome topology and function by automated multidimensional fluorescence microscopy", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 24, no. 10, 1 October 2006 (2006-10-01), pages 1270 - 1278, XP002438060, ISSN: 1087-0156, DOI: 10.1038/NBT1250
BERNDT UTA ET AL: "Proteomic analysis of the inflamed intestinal mucosa reveals distinctive immune response profiles in Crohn's disease and ulcerative collitis", JOURNAL OF IMMUNOLOGY, vol. 179, no. 1, July 2007 (2007-07-01), pages 295 - 304, XP002721811, ISSN: 0022-1767
UTA BERNDT ET AL: "Systematic high-content proteomic analysis reveals substantial immunologic changes in colorectal cancer", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 68, no. 3, 1 February 2008 (2008-02-01), pages 880 - 888, XP002618323, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-07-2923
LEHMAN BROTHERS; MC KINSEY, THE FRUITS OF GENOMICS, 2001
HUTCHINSON L; KIRCK R: "High drug attrition rates - where are we going wrong?", NAT REV CLIN ONCOL, vol. 8, 2011, pages 189 - 190, XP055346417
WORLD ALZHEIMERS REPORT, 2011
MARCELLO MALPIGHI, PRINZIP DER HISTOLOGIE BESTIMMTEN WEG NÄMLICH, pages 1628 - 1694
Attorney, Agent or Firm:
HOFSTETTER, ALFONS (DE)
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