Title:
METHOD AND DEVICE FOR EXAMINING MYOCARDIAL TOXICITY AND EVALUATING CARDIOMYOCYTE
Document Type and Number:
WIPO Patent Application WO/2013/061849
Kind Code:
A1
Abstract:
A method wherein a mass of cardiomyocytes is disposed on a transparent substrate and the quality of the cardiomyocytes is evaluated from the response of the cardiomyocytes to a forced pulsation stimulus that is applied to the pulsating cardiomyocytes. The mass of cardiomyocytes, which is disposed on the transparent substrate, is exposed to the flow of a drug-containing liquid in such a manner as to allow the drug to act on cells configuring a network. The level of cardiotoxicity caused by the drug is evaluated by measuring the fluctuations obtained from a comparison of adjacent pulsating cardiomyocytes of the network.
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Inventors:
YASUDA KENJI (JP)
KANEKO TOMOYUKI (JP)
NOMURA FUMIMASA (JP)
HATTORI AKIHIRO (JP)
KANEKO TOMOYUKI (JP)
NOMURA FUMIMASA (JP)
HATTORI AKIHIRO (JP)
Application Number:
PCT/JP2012/076860
Publication Date:
May 02, 2013
Filing Date:
October 17, 2012
Export Citation:
Assignee:
NAT UNIV CORP TOKYO MED & DENT (JP)
ON CHIP CELLOMICS CONSORTIUM (JP)
ON CHIP CELLOMICS CONSORTIUM (JP)
International Classes:
C12M1/34; C12M3/00; C12Q1/02; G01N27/30; G01N27/416
Domestic Patent References:
| WO2010064700A1 | 2010-06-10 | |||
| WO2008152983A1 | 2008-12-18 | |||
| WO2008149976A1 | 2008-12-11 | |||
| WO2012043820A1 | 2012-04-05 |
Foreign References:
| JP2008263858A | 2008-11-06 | |||
| JP2006515420A | 2006-05-25 | |||
| JP2006094703A | 2006-04-13 |
Other References:
KAZUHIRO NONAKA ET AL.: "Analysis of Cell Population Behavior on a Culture Surface Using a Particle Image Velocimetry", LIFE SUPPORT, vol. 22, no. 3, 2010, pages 125 - 131, XP055150643
FUJITA, K. ET AL.: "Time-resolved observation of surface-enhanced Raman scattering from gold nanoparticles during transport through a living cell.", J. BIOMED. OPT., vol. 14, no. 2, 2009, pages 024038 - 1 - 024038-7, XP055150647
BRENNAN M; PALANISWAMI M; KAMEN P: "Do existing measures of Poincare plot geometry reflect non-linear features of heart rate variability? Biomedical Engineering", IEEE TRANSACTIONS ON, PROC. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, vol. 48, 2001, pages 1342 - 1347
KANTERS JK; HOLSTEIN-RATHLOU NH; AGNER E: "Lack of evidence for low-dimensional chaos in heart rate variability", JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, vol. 5, no. 7, 1994, pages 591 - 601
STORELLA RJ; WOOD HW; MILLS KM ET AL.: "Approximate entropy and point correlation dimension of heart rate variability in healthy subjects", INTEGRATIVE PHYSIOLOGICAL & BEHAVIORAL SCIENCE, vol. 33, no. 4, 1994, pages 315 - 20
PATRICK DAVEY: "How to correct the QT interval for the effects of heart rate in clinical studies", JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, vol. 48, 2002, pages 3 - 9, XP055089624, DOI: doi:10.1016/S1056-8719(03)00008-X
See also references of EP 2772531A4
FUJITA, K. ET AL.: "Time-resolved observation of surface-enhanced Raman scattering from gold nanoparticles during transport through a living cell.", J. BIOMED. OPT., vol. 14, no. 2, 2009, pages 024038 - 1 - 024038-7, XP055150647
BRENNAN M; PALANISWAMI M; KAMEN P: "Do existing measures of Poincare plot geometry reflect non-linear features of heart rate variability? Biomedical Engineering", IEEE TRANSACTIONS ON, PROC. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, vol. 48, 2001, pages 1342 - 1347
KANTERS JK; HOLSTEIN-RATHLOU NH; AGNER E: "Lack of evidence for low-dimensional chaos in heart rate variability", JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, vol. 5, no. 7, 1994, pages 591 - 601
STORELLA RJ; WOOD HW; MILLS KM ET AL.: "Approximate entropy and point correlation dimension of heart rate variability in healthy subjects", INTEGRATIVE PHYSIOLOGICAL & BEHAVIORAL SCIENCE, vol. 33, no. 4, 1994, pages 315 - 20
PATRICK DAVEY: "How to correct the QT interval for the effects of heart rate in clinical studies", JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, vol. 48, 2002, pages 3 - 9, XP055089624, DOI: doi:10.1016/S1056-8719(03)00008-X
See also references of EP 2772531A4
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
Kobayashi 浩 (JP)
Kobayashi 浩 (JP)
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Claims: