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Patent Searching and Data


Title:
METHOD AND DEVICE FOR THE IDENTIFICATION OF CELL OBJECTS AND TEST COMPOUNDS EFFECTIVE AGAINST THEM
Document Type and Number:
WIPO Patent Application WO/2019/077380
Kind Code:
A3
Abstract:
The invention relates to a method for identifying test compounds that have an effect on cell objects, which comprises the following steps: a) providing a liquid sample presumably containing a cell object, b) performing mass spectrometry and/or destructive spectrophotometry testing of the liquid sample according to step a), c) comparing the mass spectrometry spectrum and/or the spectrophotometry spectrum obtained in step b) with the elements of database (s) containing such spectra of known cell objects, d) identifying the cell object present in the sample according to step a) in the course of the comparison according to step c), e) the non-destructive spectrophotometry testing of the sample according to step a), in the course of which the non-destructive spectrophotometry spectrum of the sample is recorded in such a way that test compound is not added to it, and so that test compound is added to it at a given concentration or at several different concentrations, and the recording of the spectrophotometric spectrum of the solution of the test compound, f) comparing the spectrophotometric spectrum measured in the sample without the addition of any test compound and obtained in step e) with the spectrophotometry spectrum of one or more samples prepared with the addition of the test compound, g) drawing a conclusion relating to the effective concentration of the test compound from the result of the comparison according to step f ). The invention also relates to a device serving for implementing the method.

Inventors:
MUHARI MÁRTON (HU)
LENGYEL LÁSZLÓ CSABA (HU)
SVIRZSOVICS-VÁGÓ TERÉZ MÁRIA (HU)
Application Number:
PCT/HU2018/050045
Publication Date:
October 03, 2019
Filing Date:
October 17, 2018
Export Citation:
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Assignee:
MARTIN AND CO KFT (HU)
International Classes:
C12Q1/18; B01J3/00; G01N33/48
Foreign References:
US20140104597A12014-04-17
Other References:
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WERONIKA HEWELT-BELKA ET AL: "Untargeted Lipidomics Reveals Differences in the Lipid Pattern among Clinical Isolates of Staphylococcus aureus Resistant and Sensitive to Antibiotics", JOURNAL OF PROTEOME RESEARCH, vol. 15, no. 3, 1 February 2016 (2016-02-01), pages 914 - 922, XP055564595, ISSN: 1535-3893, DOI: 10.1021/acs.jproteome.5b00915
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ANIL KUMAR MEHER ET AL: "Combination of Raman Spectroscopy and Mass Spectrometry for Online Chemical Analysis", ANALYTICAL CHEMISTRY, vol. 88, no. 18, 8 September 2016 (2016-09-08), US, pages 9151 - 9157, XP055615151, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.6b02152
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