Title:
METHOD AND DEVICE FOR PRODUCING USEFUL SUBSTANCE FROM BASIDIOMYCETES OR ASCOMYCETES USING SUBMERGED CULTURE
Document Type and Number:
WIPO Patent Application WO/2014/148132
Kind Code:
A1
Abstract:
[Problem] To provide a method and device for increasing production of and producing a useful substance by filtering and separating the mycelia of basidiomycetes or ascomycetes that have been subjected to submerged culture in a liquid medium, then adjusting the water content of the mycelia to produce a mycelium mass, storing the mycelium mass under a survivable environment, and applying stress, such as low-temperature standstill, to the mycelium mass. [Solution] Provided is a method for producing a useful substance by subjecting the mycelia of basidiomycetes or ascomycetes to submerged cultured in a liquid medium and extracting and purifying the useful substance from the resulting mycelia, and the method comprises the following: a filtration and separation step for filtering a culture liquid containing cultured mycelia and liquid medium in a culture tank and separating the mycelia; a mycelia water content adjustment step for adjusting the water content of the filtered and separated mycelia and producing a mycelium mass; and a stress application step for applying stress to the resulting mycelium mass under a survivable environment and producing a mycelium mass having an increased amount of useful substance.
Inventors:
ABE KAZUNARI (JP)
OHSHIMA TOSHIAKI (JP)
FUKUI RIKUO (JP)
OHSHIMA TOSHIAKI (JP)
FUKUI RIKUO (JP)
Application Number:
PCT/JP2014/052644
Publication Date:
September 25, 2014
Filing Date:
February 05, 2014
Export Citation:
Assignee:
ORIGIN BIOTECHNOLOGY KABUSHIKIKAISHA (JP)
International Classes:
C12N1/14; C12M1/00; C12P13/04
Foreign References:
| JP2012105618A | 2012-06-07 | |||
| JP2005185126A | 2005-07-14 | |||
| JP2003289892A | 2003-10-14 | |||
| JP2007527192A | 2007-09-27 |
Other References:
SHOJI OGA ET AL.: "Denki Pulse Inka ni yoru Tamogitake no Shijitsutai Hassei Sokushin Oyobi Ergothioneine Ganryo no Zoka", DAI 61 KAI ABSTRACTS OF THE ANNUAL MEETING OF THE JAPAN WOOD RESEARCH SOCIETY, 2011, pages 20-06-1000
GOCHEVA YANA G. ET AL.: "Temperature downshift induces antioxidant responsein fungi isolated from Antarctica", EXTREMOPHILES, vol. 13, 2009, pages 273 - 281, XP019724074
NUNES REGIANE GONCALVES FEITOSA LEA ET AL.: "Selenium Bioaccumulation in Shiitake Mushrooms: A Nutritional Alternative Source of this Element", JOURNAL OF FOOD SCIENCE, vol. 77, no. 9, 2012, pages 983 - 986
GOCHEVA YANA G. ET AL.: "Temperature downshift induces antioxidant responsein fungi isolated from Antarctica", EXTREMOPHILES, vol. 13, 2009, pages 273 - 281, XP019724074
NUNES REGIANE GONCALVES FEITOSA LEA ET AL.: "Selenium Bioaccumulation in Shiitake Mushrooms: A Nutritional Alternative Source of this Element", JOURNAL OF FOOD SCIENCE, vol. 77, no. 9, 2012, pages 983 - 986
Attorney, Agent or Firm:
KAWANAMI, Kaoru et al. (JP)
Kaoru Kawanami (JP)
Kaoru Kawanami (JP)
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