Title:
METHOD FOR DIAGNOSING ACUTE LUNG INJURY
Document Type and Number:
WIPO Patent Application WO/2012/108538
Kind Code:
A1
Abstract:
The present invention provides a useful diagnostic method and a useful diagnostic agent which are capable of diagnosing acute lung injury in clear distinction from chronic progressive interstitial pneumonia. The present invention specifically provides a method for determining whether a subject is suffering from acute lung injury or not, said method comprising quantitative determination of heat shock protein 47 in a biological sample derived from the subject.
Inventors:
KAKUGAWA TOMOYUKI (JP)
YOKOTA SHIN-ICHI (JP)
YOKOTA SHIN-ICHI (JP)
Application Number:
PCT/JP2012/053174
Publication Date:
August 16, 2012
Filing Date:
February 10, 2012
Export Citation:
Assignee:
UNIV NAGASAKI (JP)
UNIV SAPPORO MEDICAL (JP)
KAKUGAWA TOMOYUKI (JP)
YOKOTA SHIN-ICHI (JP)
UNIV SAPPORO MEDICAL (JP)
KAKUGAWA TOMOYUKI (JP)
YOKOTA SHIN-ICHI (JP)
International Classes:
G01N33/53
Foreign References:
| JPH08240593A | 1996-09-17 | |||
| JP2008122276A | 2008-05-29 | |||
| JP2003159087A | 2003-06-03 | |||
| JP2002522462A | 2002-07-23 | |||
| JP2011027679A | 2011-02-10 |
Other References:
HIDEO IWASAKA: "Dai 4 Kai Hai Surfactant Bunshi Byotai Kenkyukai - Hai Byohen no Shufuku Saisei eno Approach - Shinki Hai Shogai Inshi HMGB1 to Hai Sen'ika Inshi HSP47 kara Mita ARDS no Chiryo-ho no Kaihatsu", RESPIRATORY MOLECULAR MEDICINE, vol. 10, no. 3, 2006, pages 204 - 208, XP008168908
HIROSHI MIYAGAWA ET AL.: "Dai 4 Sho ARDS no Kiso Shikkan Haiketsusho ni Tomonau ARDS", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2004, pages 121 - 125, 214, XP008170288
HIDEO IWASAKA: "What's New in SURGERY FRONTIER Dai 67 Kai Ensho no Bunshi Kiko to Netsu Shock Tanpakushitsu 4) Heiketsusho to Netsu Shock Tanpakushitsu", SURG FRONT, vol. 17, no. 4, 2010, pages 380 - 383, XP008170434
IWASAKA HIDEO: "Three-step research strategies for ARDS: new target molecules-ACE2, HMGB1, and HSP47", J ANESTH, vol. 21, no. 1, 2007, pages 122 - 123, XP055120241
HIDEO IWASAKA: "HMGB1 to Hai Shogai (ALI/ARDS)", SURGICAL TRAUMA & IMMUNOLOGICAL RESPONSES, vol. 17, no. 2, 2008, pages 62 - 64, XP008170435
YOKOTA S ET AL.: "Prevalence of HSP47 antigen and autoantibodies to HSP47 in the sera of patients with mixed connective tissue disease", BIOCHEM BIOPHYS RES COMMUN, vol. 303, no. 2, 2003, pages 413 - 418, XP055003908
ICU & CCU, vol. 33, no. 5, 2009, pages 351 - 359
SURGICAL TRAUMA & IMMUNOLOGICALRESPONSES, vol. 17, no. 2, 2008, pages 62 - 64
THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA, vol. 23, no. 8, 2003, pages S163
SHUUKAN IGAKUNO AYUMI, BESSATSU (MARCH, 2003, pages 134 - 136
HUM PATHOL, vol. 31, 2000, pages 1498 - 1505
RESPIR RES, vol. 6, 2005, pages 57
BIOCHEM BIOPHYS RES COMMUN, vol. 3.03, 2003, pages 413 - 418
"Annals of the Japanese Respiratory Society", vol. 40, 2002, pages: 188
"Current Protocols in Molecular Biology", 2011, JOHN WILEY AND SONS
"Current protocols in Molecular Biology", 2011, JOHN WILEY AND SONS
NATSUME T. ET AL., J. BIOL. CHEM., vol. 269, 1994, pages 31224 - 31228
KOIDE, T. ET AL., J. BIOL. CHEM., vol. 281, 2006, pages 3432 - 3438
KOIDE T. ET AL., J. BIOL. CHEM., vol. 281, 2006, pages 11177 - 11185
KOIDE, T. ET AL., J. BIOL. CHEM., vol. 277, 2002, pages 6178 - 6182
TASAB, M. ET AL., J. BIOL. CHEM., vol. 277, 2002, pages 35007 - 35012
NATSUME, T. ET AL., J. BIOL. CHEM., vol. 269, 1994, pages 31224 - 31228
SHUJI MATSUO; HIROSHI TAKAHASHI: "Practical Application of Receiver Operating Characteristic Curve on Laboratory Diagnosis", RINSHO BYORI, vol. 42, 1994, pages 585 - 590
See also references of EP 2674755A4
HIROSHI MIYAGAWA ET AL.: "Dai 4 Sho ARDS no Kiso Shikkan Haiketsusho ni Tomonau ARDS", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2004, pages 121 - 125, 214, XP008170288
HIDEO IWASAKA: "What's New in SURGERY FRONTIER Dai 67 Kai Ensho no Bunshi Kiko to Netsu Shock Tanpakushitsu 4) Heiketsusho to Netsu Shock Tanpakushitsu", SURG FRONT, vol. 17, no. 4, 2010, pages 380 - 383, XP008170434
IWASAKA HIDEO: "Three-step research strategies for ARDS: new target molecules-ACE2, HMGB1, and HSP47", J ANESTH, vol. 21, no. 1, 2007, pages 122 - 123, XP055120241
HIDEO IWASAKA: "HMGB1 to Hai Shogai (ALI/ARDS)", SURGICAL TRAUMA & IMMUNOLOGICAL RESPONSES, vol. 17, no. 2, 2008, pages 62 - 64, XP008170435
YOKOTA S ET AL.: "Prevalence of HSP47 antigen and autoantibodies to HSP47 in the sera of patients with mixed connective tissue disease", BIOCHEM BIOPHYS RES COMMUN, vol. 303, no. 2, 2003, pages 413 - 418, XP055003908
ICU & CCU, vol. 33, no. 5, 2009, pages 351 - 359
SURGICAL TRAUMA & IMMUNOLOGICALRESPONSES, vol. 17, no. 2, 2008, pages 62 - 64
THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA, vol. 23, no. 8, 2003, pages S163
SHUUKAN IGAKUNO AYUMI, BESSATSU (MARCH, 2003, pages 134 - 136
HUM PATHOL, vol. 31, 2000, pages 1498 - 1505
RESPIR RES, vol. 6, 2005, pages 57
BIOCHEM BIOPHYS RES COMMUN, vol. 3.03, 2003, pages 413 - 418
"Annals of the Japanese Respiratory Society", vol. 40, 2002, pages: 188
"Current Protocols in Molecular Biology", 2011, JOHN WILEY AND SONS
"Current protocols in Molecular Biology", 2011, JOHN WILEY AND SONS
NATSUME T. ET AL., J. BIOL. CHEM., vol. 269, 1994, pages 31224 - 31228
KOIDE, T. ET AL., J. BIOL. CHEM., vol. 281, 2006, pages 3432 - 3438
KOIDE T. ET AL., J. BIOL. CHEM., vol. 281, 2006, pages 11177 - 11185
KOIDE, T. ET AL., J. BIOL. CHEM., vol. 277, 2002, pages 6178 - 6182
TASAB, M. ET AL., J. BIOL. CHEM., vol. 277, 2002, pages 35007 - 35012
NATSUME, T. ET AL., J. BIOL. CHEM., vol. 269, 1994, pages 31224 - 31228
SHUJI MATSUO; HIROSHI TAKAHASHI: "Practical Application of Receiver Operating Characteristic Curve on Laboratory Diagnosis", RINSHO BYORI, vol. 42, 1994, pages 585 - 590
See also references of EP 2674755A4
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
Download PDF:
Claims: