Title:
METHOD FOR DIAGNOSING ADULT T CELL LEUKEMIA AND METHOD FOR SCREENING THERAPEUTIC AGENT FOR ADULT T CELL LEUKEMIA
Document Type and Number:
WIPO Patent Application WO/2014/175375
Kind Code:
A1
Abstract:
Provided are: a novel method for diagnosing adult T cell leukemia, a diagnosis kit therefor; a method for screening a therapeutic agent therefor; and a therapeutic agent. The expression level of SCYL2 gene in cells is detected and the detection result is applied to the method for diagnosing adult T cell leukemia or the method for screening a therapeutic agent therefor. A phosphorylation-inhibiting and/or dephosphorylating agent, which has an effect of inhibiting phosphorylation at least at one of the phosphorylation sites of PTEN protein selected from the group consisting of T382, T383 and S380 and/or an effect of dephosphorylating the same via the regulation of the expression of SCYL2 gene, is prepared.
Inventors:
MORISHITA KAZUHIRO (JP)
ICHIKAWA TOMONAGA (JP)
NAKAHATA SHINGO (JP)
ICHIKAWA TOMONAGA (JP)
NAKAHATA SHINGO (JP)
Application Number:
PCT/JP2014/061548
Publication Date:
October 30, 2014
Filing Date:
April 24, 2014
Export Citation:
Assignee:
UNIV MIYAZAKI (JP)
International Classes:
C12Q1/68; A61K31/7088; A61K31/7105; A61K31/713; A61K38/00; A61K39/395; A61K45/00; A61K48/00; A61P25/18; A61P35/00; A61P35/02; C12N15/09; G01N33/15; G01N33/50; G01N33/53; G01N33/574; G01N33/68
Domestic Patent References:
| WO2010116899A1 | 2010-10-14 |
Foreign References:
| JP2010057371A | 2010-03-18 | |||
| JP2009189271A | 2009-08-27 | |||
| JP2007291089A | 2007-11-08 | |||
| JP2007244377A | 2007-09-27 | |||
| JP2006325440A | 2006-12-07 | |||
| JP2005147798A | 2005-06-09 | |||
| JP2010500568A | 2010-01-07 |
Attorney, Agent or Firm:
UNIUS PATENT ATTORNEYS OFFICE (JP)
Patent business corporation ユニアス international patent firm (JP)
Patent business corporation ユニアス international patent firm (JP)
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