Title:
METHOD OF DIAGNOSING BIOLOGICAL STATES THROUGH THE USE OF A CENTRALIZED, ADAPTIVE MODEL, AND REMOTE SAMPLE PROCESSING
Document Type and Number:
WIPO Patent Application WO2005060608
Kind Code:
A3
Abstract:
A model of a particular biological state can be developed. The model may be used to determine if an unknown biological sample exhibits a particular biological state. This can be done by receiving either a biological sample or data associated with the biological sample. After the data is received, the data may be input into the model. In one embodiment, the acquisition of the data associated with the biological sample is performed at a first location and the imputing of the data into the model is performed at a second location different than the first location. Unless the data maps identically to the model, the data would have an inherent effect on the position of the particular clusters within the discriminatory pattern, if it is allowed to affect the model. The modeling software can keep track of the net effect on the model that each sample received has on the position of the model. If the model has drifted outside of a predetermined tolerance, the model can be updated. Various business relationships may be developed to undertake various steps of the overall method for providing a diagnosis to a patient.
Inventors:
CHEN TZONG-HOA (US)
HITT BEN A (US)
LEVINE PETER J (US)
HITT BEN A (US)
LEVINE PETER J (US)
Application Number:
PCT/US2004/041135
Publication Date:
August 17, 2006
Filing Date:
December 10, 2004
Export Citation:
Assignee:
CORRELOGIC SYSTEMS INC (US)
CHEN TZONG-HOA (US)
HITT BEN A (US)
LEVINE PETER J (US)
CHEN TZONG-HOA (US)
HITT BEN A (US)
LEVINE PETER J (US)
International Classes:
G01N33/48; G01N33/50; G16B40/10; G16B50/00
Other References:
BALTESKARD L. ET AL.: "Medical Diagnosis in the Internet Age", LANCET, vol. 354, December 1999 (1999-12-01), pages SIV 14, XP004815272
LOGING W.T. ET AL.: "Identifying Potential Tumor Markers and Antigens by Database Mining and Rapid Expression Screening", GENOME RESEARCH, vol. 10, September 2000 (2000-09-01), pages 1393 - 1402, XP003000389
ADAM B.-L. ET AL.: "Serum Protein Fingerprinting Coupled with a Pattern-matching Algorithm Distinguishes Prostate Cancer from Benigh Prostate Hyperplasia and Healthy Men", CANCER RESEARCH, vol. 62, July 2002 (2002-07-01), pages 3609 - 3614, XP002975917
BROWN M.P.S. ET AL.: "Knowledge-based Analysis of Microarray Gene Expression Data by Using Support Vector Machines", PNAS, vol. 97, January 2000 (2000-01-01), pages 262 - 267, XP002909076
LOGING W.T. ET AL.: "Identifying Potential Tumor Markers and Antigens by Database Mining and Rapid Expression Screening", GENOME RESEARCH, vol. 10, September 2000 (2000-09-01), pages 1393 - 1402, XP003000389
ADAM B.-L. ET AL.: "Serum Protein Fingerprinting Coupled with a Pattern-matching Algorithm Distinguishes Prostate Cancer from Benigh Prostate Hyperplasia and Healthy Men", CANCER RESEARCH, vol. 62, July 2002 (2002-07-01), pages 3609 - 3614, XP002975917
BROWN M.P.S. ET AL.: "Knowledge-based Analysis of Microarray Gene Expression Data by Using Support Vector Machines", PNAS, vol. 97, January 2000 (2000-01-01), pages 262 - 267, XP002909076
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