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Title:
METHOD FOR DIAGNOSING CARDIAC DISEASE THROUGH BACTERIAL METAGENOME ANALYSIS
Document Type and Number:
WIPO Patent Application WO/2018/111028
Kind Code:
A1
Abstract:
The present invention relates to a method for diagnosing cardiac disease through bacterial metagenome analysis. More specifically, the present invention relates to a method for predicting the causative factor and onset of cardiac disease, diagnosing cardiac disease early, and predicting prognosis by analyzing the increase or decrease in the content of an extracellular vesicle derived from specific bacteria by performing bacterial metagenome analysis using a specimen-derived sample. Through metagenome analysis of a bacteria-derived extracellular vesicle using a human body-derived sample according to the present invention, the risk of the onset of cardiac disease is predicted in advance, and thus a risk group for cardiac disease is diagnosed and predicted early. Accordingly, through suitable management, the moment of onset of disease can be delayed or the onset of the disease can be prevented, and early diagnosis can be performed even after the the onset of disease. Therefore, the rate of onset of cardiac disease can be reduced, and the effect of treatment can be improved. In addition, since exposure to causative factors is avoided through metagenome analysis in a patient diagnosed with cardiac disease, the prognosis of cardiac disease can be improved, or reoccurrence of cardiac disease can be prevented.

Inventors:
KIM YOON-KEUN (KR)
Application Number:
KR2017/014815
Publication Date:
June 21, 2018
Filing Date:
December 15, 2017
Export Citation:
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Assignee:
MD HEALTHCARE INC (03923, KR)
International Classes:
C12Q1/68
Domestic Patent References:
WO2012050513A12012-04-19
Foreign References:
KR20160073157A2016-06-24
US20140086954A12014-03-27
US20150232934A12015-08-20
Other References:
YUANA, Y. ET AL.: "Extracellular Vesicles in Physiological and Pathological Conditions", BLOOD REVIEWS, vol. 27, no. 1, 1 January 2013 (2013-01-01), pages 31 - 39, XP055495785, Retrieved from the Internet
Attorney, Agent or Firm:
LEE, Myoung-Jin (6th floor, 28 Yeongdong-daero 85-gil,,Gangnam-gu, Seoul, 06180, KR)
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