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Title:
METHOD FOR DIAGNOSING LUNG CANCER VIA BACTERIAL METAGENOMIC ANALYSIS
Document Type and Number:
WIPO Patent Application WO/2018/124617
Kind Code:
A1
Abstract:
The present invention relates to a method for diagnosing lung cancer via bacterial metagenomic analysis and, more particularly, to a method for diagnosing lung cancer by performing bacterial metagenomic analysis using a subject-derived sample, and by analyzing an increase or decrease in the content of a specific bacterium-derived extracellular vesicle. An extracellular vesicle secreted from a bacterium present in the environment can be absorbed into the body and directly affect the occurrence of cancer, and lung cancer is difficult to diagnose early on before any symptom appears, which makes efficient treatment difficult. As such, through the metagenomic analysis on a gene present in a bacterium-derived extracellular vesicle using a human body-derived sample according to the present invention, the risk of the onset of lung cancer can be predicted in advance, enabling early diagnosis and prediction of a lung cancer risk group and delay of the time of the onset or prevention of the onset with proper care, and early diagnosis is still possible even after the onset, which can lower the incidence rate of lung cancer and enhance the treatment effect.

Inventors:
KIM YOON-KEUN (KR)
JEON SEONG GYU (KR)
Application Number:
PCT/KR2017/015173
Publication Date:
July 05, 2018
Filing Date:
December 21, 2017
Export Citation:
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Assignee:
MD HEALTHCARE INC (KR)
AEON MEDIX INC (KR)
International Classes:
C12Q1/68
Foreign References:
KR20110025603A2011-03-10
KR20160101521A2016-08-25
KR20120114872A2012-10-17
KR20130021920A2013-03-06
Other References:
YAN, X. ET AL.: "Discovery and Validation of Potential Bacterial Biomarkers for Lung Cancer", AMERICAN JOURNAL OF CANCER RESEARCH, vol. 5, no. 10, 15 September 2015 (2015-09-15), pages 3111 - 3122, XP055516990
HANDELSMAN ET AL., CHEM. BIOL., vol. 5, 1998, pages R245 - 249
See also references of EP 3561069A4
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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