Title:
METHOD FOR DIAGNOSING MALIGNANT TUMOR
Document Type and Number:
WIPO Patent Application WO/2011/074594
Kind Code:
A1
Abstract:
Provided are a method for determining the presence of a malignant tumor or the severity thereof, selecting a therapeutic method therefor or evaluating the effect of said therapeutic method, or estimating the recurrence risk of said malignant tumor or the presence or absence of the recurrence of the same, and a diagnostic kit for the same purposes.
The method for determining the presence of a malignant tumor or the severity thereof, selecting a therapeutic method therefor or evaluating the effect of said therapeutic method, or estimating the recurrence risk of said malignant tumor or the presence or absence of the recurrence of the same is characterized by comprising: a step (1) for measuring the concentration and/or quantity of soluble LR11 in a sample originating in a subject; and a step (2) for comparing the measurement data with the measurement data of soluble LR11 obtained from a group of normal subjects.
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Inventors:
EBINUMA HIROYUKI (JP)
TAKUBO KOHEI (JP)
MATSUO MASANAO (JP)
FUKAMACHI ISAMU (JP)
BUJO HIDEAKI (JP)
NAKASEKO CHIAKI (JP)
SAITO YASUSHI (JP)
TAKUBO KOHEI (JP)
MATSUO MASANAO (JP)
FUKAMACHI ISAMU (JP)
BUJO HIDEAKI (JP)
NAKASEKO CHIAKI (JP)
SAITO YASUSHI (JP)
Application Number:
PCT/JP2010/072521
Publication Date:
June 23, 2011
Filing Date:
December 15, 2010
Export Citation:
Assignee:
SEKISUI MEDICAL CO LTD (JP)
EBINUMA HIROYUKI (JP)
TAKUBO KOHEI (JP)
MATSUO MASANAO (JP)
FUKAMACHI ISAMU (JP)
BUJO HIDEAKI (JP)
NAKASEKO CHIAKI (JP)
SAITO YASUSHI (JP)
EBINUMA HIROYUKI (JP)
TAKUBO KOHEI (JP)
MATSUO MASANAO (JP)
FUKAMACHI ISAMU (JP)
BUJO HIDEAKI (JP)
NAKASEKO CHIAKI (JP)
SAITO YASUSHI (JP)
International Classes:
G01N33/574; G01N33/566
Domestic Patent References:
| WO2008155891A1 | 2008-12-24 | |||
| WO2009116268A1 | 2009-09-24 |
Foreign References:
| JPH09163988A | 1997-06-24 |
Other References:
HIRAYAMA, S. ET AL.: "Differential Expression of LR11 during Proliferation and Differentiation of Cultured Neuroblastoma Cells.", BIOCHEM. BIOPHYS.RES.COMMUN., vol. 275, no. 2, 2000, pages 365 - 373, XP008158821
MEIZI JIANG ET AL.: "Naimaku Heikatsukin Saibo no Tokuiteki Hatsugen Idenshi LR11 wa Keishitsu Henkan o Seigyo suru", ANNUAL SCIENTIFIC METTING OF THE JAPAN ATHEROSCLEROSIS SOCIETY PROGRAM SHOROKUSHU, vol. 38, 1 July 2006 (2006-07-01), pages 272, XP008159058
TADANAO MATSUO ET AL.: "Kayosei LR11 no ELISA ni yoru Sokutei-kei no Kaihatsu", ANNUAL SCIENTIFIC METTING OF THE JAPAN ATHEROSCLEROSIS SOCIETY PROGRAM SHOROKUSHU, vol. 40, 27 June 2008 (2008-06-27), pages 239, XP008143596
OHWADA, C. ET AL.: "Prognostic impact of serum soluble LR11 on acute leukemias", THE JAPANESE JOURNAL OF CLINICAL HEMATOLOGY, vol. 51, no. 9, 30 September 2010 (2010-09-30), pages 1016, XP008155813
TAKEUCHI, M. ET AL.: "LR11 is a novel surface marker for normal leukocyte and leukemia cells", THE JAPANESE JOURNAL OF CLINICAL HEMATOLOGY, vol. 51, no. 9, 30 September 2010 (2010-09-30), pages 1015, XP008158812
SAKAI, S. ET AL.: "Soluble LR11 is a novel biomarker for acute leukemias", THE JAPANESE JOURNAL OF CLINICAL HEMATOLOGY, vol. 51, no. 9, 30 September 2010 (2010-09-30), pages 926, XP008158811
J. BIOL. CHEM., vol. 271, 1996, pages 24761 - 24768
ARTERIOSCLER. THROMB. VASC. BIOL., vol. 19, 1999, pages 2687 - 2695
J. CLIN. INVEST., vol. 118, 2008, pages 2733 - 2746
CLIN. CHEM., vol. 55, 2009, pages 1801 - 1808
"Monoclonal Antibody", 1990, HIROKAWA- SHOTEN
JAME W. GOLDING: "Monoclonal Antibody, 3rd edition,", 1996, ACADEMIC PRESS
NATURE, vol. 356, 12 March 1992 (1992-03-12), pages 152 - 154
J. IMMUNOL. METHODS, vol. 249, pages 147 - 154
MEIZI JIANG ET AL.: "Naimaku Heikatsukin Saibo no Tokuiteki Hatsugen Idenshi LR11 wa Keishitsu Henkan o Seigyo suru", ANNUAL SCIENTIFIC METTING OF THE JAPAN ATHEROSCLEROSIS SOCIETY PROGRAM SHOROKUSHU, vol. 38, 1 July 2006 (2006-07-01), pages 272, XP008159058
TADANAO MATSUO ET AL.: "Kayosei LR11 no ELISA ni yoru Sokutei-kei no Kaihatsu", ANNUAL SCIENTIFIC METTING OF THE JAPAN ATHEROSCLEROSIS SOCIETY PROGRAM SHOROKUSHU, vol. 40, 27 June 2008 (2008-06-27), pages 239, XP008143596
OHWADA, C. ET AL.: "Prognostic impact of serum soluble LR11 on acute leukemias", THE JAPANESE JOURNAL OF CLINICAL HEMATOLOGY, vol. 51, no. 9, 30 September 2010 (2010-09-30), pages 1016, XP008155813
TAKEUCHI, M. ET AL.: "LR11 is a novel surface marker for normal leukocyte and leukemia cells", THE JAPANESE JOURNAL OF CLINICAL HEMATOLOGY, vol. 51, no. 9, 30 September 2010 (2010-09-30), pages 1015, XP008158812
SAKAI, S. ET AL.: "Soluble LR11 is a novel biomarker for acute leukemias", THE JAPANESE JOURNAL OF CLINICAL HEMATOLOGY, vol. 51, no. 9, 30 September 2010 (2010-09-30), pages 926, XP008158811
J. BIOL. CHEM., vol. 271, 1996, pages 24761 - 24768
ARTERIOSCLER. THROMB. VASC. BIOL., vol. 19, 1999, pages 2687 - 2695
J. CLIN. INVEST., vol. 118, 2008, pages 2733 - 2746
CLIN. CHEM., vol. 55, 2009, pages 1801 - 1808
"Monoclonal Antibody", 1990, HIROKAWA- SHOTEN
JAME W. GOLDING: "Monoclonal Antibody, 3rd edition,", 1996, ACADEMIC PRESS
NATURE, vol. 356, 12 March 1992 (1992-03-12), pages 152 - 154
J. IMMUNOL. METHODS, vol. 249, pages 147 - 154
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
Patent business corporation Alga patent firm (JP)
Patent business corporation Alga patent firm (JP)
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