Title:
METHOD FOR DIAGNOSING PROSTATIC DISEASE VIA BACTERIAL METAGENOMIC ANALYSIS
Document Type and Number:
WIPO Patent Application WO/2018/124742
Kind Code:
A1
Abstract:
The present invention relates to a method for diagnosing a prostatic disease, such as prostate cancer and prostatic hypertrophy, via bacterial metagenomic analysis and, more particularly, to a method for diagnosing prostate cancer and prostatic hypertrophy by performing bacterial metagenomic analysis by using a subject-derived sample, and analyzing an increase or decrease in the content of a specific bacterium-derived extracellular vesicle. An extracellular vesicle secreted from a bacterium present in the environment can be absorbed into the body and directly affect the occurrence of inflammation and cancer, and a prostatic disease, such as prostate cancer and prostatic hypertrophy, is difficult to diagnose early on before any symptom appears, which makes efficient treatment difficult. As such, through the metagenomic analysis of a gene present in a bacterium-derived extracellular vesicle using a human body-derived sample according to the present invention, the risk of the onset of prostate cancer and prostatic hypertrophy can be predicted in advance, enabling early diagnosis and prediction of a prostatic disease risk group and delay of the time of the onset or prevention of the onset with proper care, and early diagnosis is still possible even after the onset of prostatic hypertrophy or prostate cancer, which can lower the incidence rate of the prostatic disease and enhance the treatment effect.
Inventors:
KIM YOON-KEUN (KR)
Application Number:
PCT/KR2017/015576
Publication Date:
July 05, 2018
Filing Date:
December 27, 2017
Export Citation:
Assignee:
MD HEALTHCARE INC (KR)
International Classes:
C12Q1/68
Domestic Patent References:
| WO2016099076A1 | 2016-06-23 |
Foreign References:
| KR20110025603A | 2011-03-10 | |||
| KR20110073049A | 2011-06-29 |
Other References:
YU , HAINING ET AL.: "Urinaiy Microbiota in Patients with Prostate Cancer and Benign Prostatic Hyperplasia", ARCHIVES OF MEDICAL SCIENCE, vol. 2, 23 April 2015 (2015-04-23), pages 385 - 394, XP055515121
SMELOV, VITALY ET AL.: "Metagenomic Sequencing of Expressed Prostate Secretions", JOURNAL OF MEDICAL VIROLOGY, vol. 86, no. 12, December 2014 (2014-12-01), pages 2042 - 2048, XP055515126
PARK, YONG HYUN ET AL.: "Prostate-specific Extracellular Vesicles as a Novel Biomarker in Human Prostate Cancer", SCIENTIFIC REPORTS, vol. 6, 9 August 2016 (2016-08-09), pages 1 - 8, XP055515129
SMELOV, VITALY ET AL.: "Metagenomic Sequencing of Expressed Prostate Secretions", JOURNAL OF MEDICAL VIROLOGY, vol. 86, no. 12, December 2014 (2014-12-01), pages 2042 - 2048, XP055515126
PARK, YONG HYUN ET AL.: "Prostate-specific Extracellular Vesicles as a Novel Biomarker in Human Prostate Cancer", SCIENTIFIC REPORTS, vol. 6, 9 August 2016 (2016-08-09), pages 1 - 8, XP055515129
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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