Title:
METHOD FOR DIAGNOSING RENAL FAILURE VIA BACTERIAL METAGENOMIC ANALYSIS
Document Type and Number:
WIPO Patent Application WO/2018/124726
Kind Code:
A1
Abstract:
The present invention relates to a method for diagnosing renal failure via bacterial metagenomic analysis and, more particularly, to a method for diagnosing renal failure by performing bacterial metagenomic analysis using a subject-derived sample, and by analyzing an increase or decrease in the content of a specific bacterium-derived extracellular vesicle. An extracellular vesicle secreted from a microbe, such as a bacterium and an archaeon, present in the environment can be absorbed into the body and directly affect the renal function, and renal failure is difficult to diagnose early on before any symptom appears, which makes efficient treatment difficult. As such, through the metagenomic analysis of a bacterium-derived extracellular vesicle using a human body-derived sample according to the present invention, the risk of the onset of renal failure can be predicted in advance, enabling early diagnosis and prediction of a renal failure risk group and delay of the time of the onset or prevention of the onset with proper care, and early diagnosis is still possible even after the onset, which can lower the incidence rate of renal failure and enhance the treatment effect.
Inventors:
KIM YOON-KEUN (KR)
Application Number:
PCT/KR2017/015537
Publication Date:
July 05, 2018
Filing Date:
December 27, 2017
Export Citation:
Assignee:
MD HEALTHCARE INC (KR)
International Classes:
C12Q1/68
Foreign References:
| KR20160073157A | 2016-06-24 | |||
| KR20110025603A | 2011-03-10 | |||
| KR20060019700A | 2006-03-06 |
Other References:
VAZIRI, NOSRATOLA D.: "Altered intestinal microbial flora and impaired epithelial barrier structure and function in CKD: the nature , mechanisms, consequences and potential treatment", NEPHROLOGY DIALYSIS TRANSPLANTATION, vol. 31, no. 5, 16 April 2015 (2015-04-16), pages 737 - 746, XP055607374
ERDBRUGGER, UTA: "Extracellular vesicles in renal diseases: more than novel biomarkers?", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 27, no. 1, 6 August 2015 (2015-08-06), pages 12 - 26, XP055607375
ERDBRUGGER, UTA: "Extracellular vesicles in renal diseases: more than novel biomarkers?", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 27, no. 1, 6 August 2015 (2015-08-06), pages 12 - 26, XP055607375
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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