Title:
METHOD OF DIAGNOSING UVEITIS
Document Type and Number:
WIPO Patent Application WO/2005/113806
Kind Code:
A1
Abstract:
It is intended to economically and effectively diagnose uveitis. Namely, a method of diagnosing uveitis in an individual which comprises measuring the gene expression level of at least one chemokine receptor selected from the group consisting of CCR4, CXCR1, CX3CR1 and CXCR4 in a sample originating in the individual, for example, body fluid such as blood, leucocytes, lymphocytes, monocytes, activated T cells, dendritic cells, eosinophils, NK cells, basophils, Th2 cells, Tc1 cells, Tc2 cells, matured dendritic cells and so on.
Inventors:
OKAMURA HIROSHI (JP)
HIRAYAMA KOUICHI (JP)
YAMANO HIROFUMI (JP)
SONODA KOH-HEI (JP)
HIRAYAMA KOUICHI (JP)
YAMANO HIROFUMI (JP)
SONODA KOH-HEI (JP)
Application Number:
PCT/JP2005/008950
Publication Date:
December 01, 2005
Filing Date:
May 17, 2005
Export Citation:
Assignee:
TOYO KOHAN CO LTD (JP)
KYUSHU TLO CO LTD (JP)
OKAMURA HIROSHI (JP)
HIRAYAMA KOUICHI (JP)
YAMANO HIROFUMI (JP)
SONODA KOH-HEI (JP)
KYUSHU TLO CO LTD (JP)
OKAMURA HIROSHI (JP)
HIRAYAMA KOUICHI (JP)
YAMANO HIROFUMI (JP)
SONODA KOH-HEI (JP)
International Classes:
G01N33/50; C12M1/00; C12N15/09; C12Q1/68; G01N33/15; G01N33/53; G01N33/551; G01N33/564; G01N33/68; G01N37/00; (IPC1-7): C12Q1/68; C12M1/00; C12N15/09; G01N33/15; G01N33/50; G01N33/53; G01N33/551; G01N37/00
Other References:
KLITGAARD T.L.S. ET AL: "Chemokine receptors and early activation markers in acute anterior uveitis.", ACTA OPHTHALMOLOGICA SCANDINAVICA, vol. 82, no. 2, April 2004 (2004-04-01), pages 179 - 183, XP002997645
ADAMUS G ET AL: "Expression of CC chemokines and their receptors in the eye in autoimmune anterior uveitis associated with EAE.", INVEST OPHTHALMOL VIS SCI., vol. 42, no. 12, 2001, pages 2894 - 2903, XP009026619
KANEKO F. ET AL: "Behcet's Disease Kanja Masshoketsu Hakkekkyu ni okeru Chemokine Juyotai Hatsugen no Kan'yo ni Tsuite.", 2002, pages 60 - 63, XP002997646
ADAMUS G ET AL: "Expression of CC chemokines and their receptors in the eye in autoimmune anterior uveitis associated with EAE.", INVEST OPHTHALMOL VIS SCI., vol. 42, no. 12, 2001, pages 2894 - 2903, XP009026619
KANEKO F. ET AL: "Behcet's Disease Kanja Masshoketsu Hakkekkyu ni okeru Chemokine Juyotai Hatsugen no Kan'yo ni Tsuite.", 2002, pages 60 - 63, XP002997646
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