Title:
METHOD FOR THE DIAGNOSIS OR THE PROGNOSIS OF ALZHEIMER DISEASE THERAPEUTICAL COMPOSITION FOR PREVENTING OR TREATING ALZHEIMER DISEASE
Document Type and Number:
WIPO Patent Application WO2001004349
Kind Code:
A3
Abstract:
The invention relates to a method of predicting an increased risk of a patient having Alzheimer's disease (AD) or for a subject of developing AD comprising: a) assaying a DNA-containing biological sample for the allele of the APOE gene; b) assaying the plasmatic level of protein Lp(a) or glycoprotein Apo(a), wherein the presence of an epsilon 4 allele of the APOE gene and an increased plasmatic level of [Lp(a)]/Apo(a) indicates an increased risk for the patient having Alzheimer's disease or developing AD. The invention further provides a therapy for preventing or treating AD consisting of decreasing the plasmatic level of Lp(a) or the interaction of Lp(a) with its receptor in a patient bearing at least one APOE epsilon 4 allele.
More Like This:
| JP2010504285 | Dendrimer composition |
| WO/2003/049743 | COMBINATION CANCER THERAPY |
| JP2018197276 | METHODS AND COMPOSITIONS FOR TREATMENT OF ATTENTION DEFICIT DISORDER |
Inventors:
MOOSER VINCENT (CH)
HELBECQUE NICOLE (FR)
AMOUYEL PHILIPPE (FR)
HELBECQUE NICOLE (FR)
AMOUYEL PHILIPPE (FR)
Application Number:
PCT/EP2000/006730
Publication Date:
May 25, 2001
Filing Date:
July 07, 2000
Export Citation:
Assignee:
PASTEUR INSTITUT (FR)
CHU VAUDOIS LAUSANNE (CH)
INST NAT SANTE RECH MED (FR)
MOOSER VINCENT (CH)
HELBECQUE NICOLE (FR)
AMOUYEL PHILIPPE (FR)
CHU VAUDOIS LAUSANNE (CH)
INST NAT SANTE RECH MED (FR)
MOOSER VINCENT (CH)
HELBECQUE NICOLE (FR)
AMOUYEL PHILIPPE (FR)
International Classes:
A61K31/132; A61K31/198; A61K31/20; A61K31/203; A61K31/58; G01N33/53; A61K31/7088; A61K38/00; A61K38/16; A61K38/17; A61K38/55; A61K39/395; A61K45/00; A61P25/28; C12Q1/02; C12Q1/68; C12Q1/6883; G01N33/92; (IPC1-7): C12Q1/68; G01N33/68; A61K38/46; A61K31/20; A61P25/28
Domestic Patent References:
| WO1995024504A1 | 1995-09-14 | |||
| WO1998018429A2 | 1998-05-07 | |||
| WO1996009392A1 | 1996-03-28 |
Other References:
KUO Y-M, ET AL.: "Elevated low-density lipoprotein in Alzheimer's Disease correlates with brain Abeta 1-42 levels", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 252, 1998, pages 711 - 715, XP002126049
KURIYAMA M ET AL: "Low levels of aoplipoprotein A1 and A11 in senile dementia", JAPANESE JOURNAL OF PSYCHIATRY AND NEUROLOGY, vol. 48, no. 3, - September 1994 (1994-09-01), pages 589 - 93, XP000863586
KURIYAMA M ET AL: "Low levels of aoplipoprotein A1 and A11 in senile dementia", JAPANESE JOURNAL OF PSYCHIATRY AND NEUROLOGY, vol. 48, no. 3, - September 1994 (1994-09-01), pages 589 - 93, XP000863586
Download PDF: