Title:
METHOD OF THE DIAGNOSIS OF RENAL DISORDER, HEMOLYTIC-UREMIC SYNDROME AND INTESTINAL HEMORRHAGIC ESCHERICHIA COLI INFECTION
Document Type and Number:
WIPO Patent Application WO/2001/027620
Kind Code:
A1
Abstract:
A method of the early diagnosis of renal disorder, hemolytic-uremic syndrome and intestinal hemorrhagic Escherichia coli infection at the early stage; and a method of judging the severity of these diseases. The attack of renal disorder, hemolytic-uremic syndrome or intestinal hemorrhagic E. coli infection or the severity thereof is judged by detecting or quantitating AQP2 and/or molecules originating therein excreted into the urine of a subject. An immunochemical method with the use of an antibody specifically recognizing AQP2 is appropriately employed in the detection or quantification.
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Inventors:
MIWA KUNIO (JP)
SUGATANI JUNKO (JP)
SUGATANI JUNKO (JP)
Application Number:
PCT/JP2000/006972
Publication Date:
April 19, 2001
Filing Date:
October 06, 2000
Export Citation:
Assignee:
FUSO PHARMACEUTICAL IND (JP)
MIWA KUNIO (JP)
SUGATANI JUNKO (JP)
MIWA KUNIO (JP)
SUGATANI JUNKO (JP)
International Classes:
G01N33/569; (IPC1-7): G01N33/53; G01N33/68
Domestic Patent References:
| WO1998043997A1 | 1998-10-08 |
Other References:
SEI SASAKI: "Aquaporin", IGAKU NO AYUMI, vol. 173, no. 9, 27 May 1995 (1995-05-27), pages 745 - 748, XP002934272
DATABASE BIOSIS [online] ISHIKAWA: "Urinary excretion of aquaporin-2 in pathological states of water metabolism", XP002903088, Database accession no. PREV200000189017
DATABASE BIOSIS [online] ISHIKAWA: "Urinary excretion of aquaporin-2 in pathological states of water metabolism", XP002903088, Database accession no. PREV200000189017
Attorney, Agent or Firm:
Sumida, Yoshihiro (3rd Floor 123-1 Higashimachi Chuo-ku, Kobe-shi Hyogo, JP)
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