Title:
METHOD FOR DIAGNOSIS OF UNSTABLE ATHEROSCLEROTIC PLAQUES
Document Type and Number:
WIPO Patent Application WO/2018/202931
Kind Code:
A3
Abstract:
The present invention relates to a method for diagnosing unstable atherosclerosis plaques, using a method to determine the probability of a person suffering from a cerebrovascular disease and a method to select a patient that could be treated with a therapy to eliminate or stabilise the carotid atherosclosis plaque on the basis of the determination of the expression level of at least one gene selected from the group of genes shown in table 1. The invention also relates to a kit comprising suitable reagents for determining the expression levels of at least one gene selected from the group of genes shown in table 1 and, optionally, reagents for determining the expression levels of one or more caretaker genes, and to the uses of said kit.
Inventors:
ALLOZA MORAL IRAIDE (ES)
VANDENBROECK KOEN (ES)
FREIJO GUERRERO MARÍA DEL MAR (ES)
VEGA MANRIQUE REYES (ES)
VANDENBROECK KOEN (ES)
FREIJO GUERRERO MARÍA DEL MAR (ES)
VEGA MANRIQUE REYES (ES)
Application Number:
PCT/ES2018/070338
Publication Date:
March 14, 2019
Filing Date:
May 04, 2018
Export Citation:
Assignee:
UNIV DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA (ES)
ADMINISTRACION GENERAL DE LA COMUNIDAD AUTONOMA DE EUSKADI (ES)
ADMINISTRACION GENERAL DE LA COMUNIDAD AUTONOMA DE EUSKADI (ES)
International Classes:
C12Q1/6883
Domestic Patent References:
| WO2012004301A1 | 2012-01-12 | |||
| WO2004057031A2 | 2004-07-08 | |||
| WO2006026074A2 | 2006-03-09 |
Foreign References:
| US20130330333A1 | 2013-12-12 |
Other References:
ZHE WANG ET AL: "Integrated Analysis of Microarray Data of Atherosclerotic Plaques: Modulation of the Ubiquitin-Proteasome System", PLOS ONE, vol. 9, no. 10, 15 October 2014 (2014-10-15), pages e110288, XP055511141, DOI: 10.1371/journal.pone.0110288
JIAN WANG ET AL: "Identification by microarray technology of key genes involved in the progression of carotid atherosclerotic plaque", GENES AND GENETIC SYSTEMS, vol. 89, no. 6, 1 January 2014 (2014-01-01), JP, pages 253 - 258, XP055511140, ISSN: 1341-7568, DOI: 10.1266/ggs.89.253
JANI SAKSI ET AL: "Gene expression differences between stroke-associated and asymptomatic carotid plaques", JOURNAL OF MOLECULAR MEDICINE, SPRINGER, BERLIN, DE, vol. 89, no. 10, 24 May 2011 (2011-05-24), pages 1015 - 1026, XP019950171, ISSN: 1432-1440, DOI: 10.1007/S00109-011-0773-Z
STEFAN SALCHER ET AL: "C10ORF10/DEPP, a transcriptional target of FOXO3, regulates ROS-sensitivity in human neuroblastoma", MOLECULAR CANCER, BIOMED CENTRAL, LONDON, GB, vol. 13, no. 1, 28 September 2014 (2014-09-28), pages 224, XP021199523, ISSN: 1476-4598, DOI: 10.1186/1476-4598-13-224
IRAIDE ALLOZA ET AL: "RNAseq based transcriptomics study of SMCs from carotid atherosclerotic plaque: BMP2 and IDs proteins are crucial regulators of plaque stability", SCIENTIFIC REPORTS, vol. 7, no. 1, 14 June 2017 (2017-06-14), XP055511977, DOI: 10.1038/s41598-017-03687-9
NIKU OKSALA ET AL: "Carbonic anhydrases II and XII are up-regulated in osteoclast-like cells in advanced human atherosclerotic plaques-Tampere Vascular Study", ANNALS OF MEDICINE, vol. 42, no. 5, 28 May 2010 (2010-05-28), SE, pages 360 - 370, XP055301185, ISSN: 0785-3890, DOI: 10.3109/07853890.2010.486408
PETER R. SINNAEVE ET AL: "Gene Expression Patterns in Peripheral Blood Correlate with the Extent of Coronary Artery Disease", PLOS ONE, vol. 4, no. 9, 14 September 2009 (2009-09-14), pages e7037, XP055547500, DOI: 10.1371/journal.pone.0007037
JIAN WANG ET AL: "Identification by microarray technology of key genes involved in the progression of carotid atherosclerotic plaque", GENES AND GENETIC SYSTEMS, vol. 89, no. 6, 1 January 2014 (2014-01-01), JP, pages 253 - 258, XP055511140, ISSN: 1341-7568, DOI: 10.1266/ggs.89.253
JANI SAKSI ET AL: "Gene expression differences between stroke-associated and asymptomatic carotid plaques", JOURNAL OF MOLECULAR MEDICINE, SPRINGER, BERLIN, DE, vol. 89, no. 10, 24 May 2011 (2011-05-24), pages 1015 - 1026, XP019950171, ISSN: 1432-1440, DOI: 10.1007/S00109-011-0773-Z
STEFAN SALCHER ET AL: "C10ORF10/DEPP, a transcriptional target of FOXO3, regulates ROS-sensitivity in human neuroblastoma", MOLECULAR CANCER, BIOMED CENTRAL, LONDON, GB, vol. 13, no. 1, 28 September 2014 (2014-09-28), pages 224, XP021199523, ISSN: 1476-4598, DOI: 10.1186/1476-4598-13-224
IRAIDE ALLOZA ET AL: "RNAseq based transcriptomics study of SMCs from carotid atherosclerotic plaque: BMP2 and IDs proteins are crucial regulators of plaque stability", SCIENTIFIC REPORTS, vol. 7, no. 1, 14 June 2017 (2017-06-14), XP055511977, DOI: 10.1038/s41598-017-03687-9
NIKU OKSALA ET AL: "Carbonic anhydrases II and XII are up-regulated in osteoclast-like cells in advanced human atherosclerotic plaques-Tampere Vascular Study", ANNALS OF MEDICINE, vol. 42, no. 5, 28 May 2010 (2010-05-28), SE, pages 360 - 370, XP055301185, ISSN: 0785-3890, DOI: 10.3109/07853890.2010.486408
PETER R. SINNAEVE ET AL: "Gene Expression Patterns in Peripheral Blood Correlate with the Extent of Coronary Artery Disease", PLOS ONE, vol. 4, no. 9, 14 September 2009 (2009-09-14), pages e7037, XP055547500, DOI: 10.1371/journal.pone.0007037
Attorney, Agent or Firm:
ARIAS SANZ, Juan (ES)
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