Title:
METHOD AND DIAGNOSTIC DEVICE FOR DETERMINING PRESENCE OR ABSENCE OF CONSTIPATION USING MACHINE LEARNING MODEL
Document Type and Number:
WIPO Patent Application WO/2022/203353
Kind Code:
A1
Abstract:
A method for determining the presence or absence of constipation using a machine learning model may comprise the steps of: analyzing a mixture obtained by mixing an intestine-derived material collected from an individual with an intestinal environmental-like composition; extracting a plurality of microorganism data on the basis the analysis result of the mixture; selecting a microorganism-related variable to be used in a machine learning model from among the plurality of microorganism data on the basis of a preset variable selection algorithm; training the machine learning model by using the microorganism-related variable; and determine the presence or absence of constipation by inputting the microorganism data collected from an object to be tested into the trained machine learning model. The microorganism-related variable may include the content the content of one or more microorganisms selected from the genus belonging to the families Lachnospiraceae, Erysipelatoclostridiaceae, Pseudomondaeae, Prevotellaceae, Desulfovibrionaceae, Clostridiaceae, Gemellaceae, Bacteroidaceae, Streptococcusae, Anaerofustaceae, Monoglobaceae, and RF39.
Inventors:
JI YO SEP (KR)
PARK SO YOUNG (KR)
PARK SO YOUNG (KR)
Application Number:
PCT/KR2022/003982
Publication Date:
September 29, 2022
Filing Date:
March 22, 2022
Export Citation:
Assignee:
HEM PHARMA INC (KR)
International Classes:
G16B40/20; G06N20/00; G16B5/00; G16C20/10; G16H50/20
Domestic Patent References:
| WO2014121298A2 | 2014-08-07 |
Foreign References:
| KR20200054203A | 2020-05-19 | |||
| US20120149584A1 | 2012-06-14 | |||
| KR102373888B1 | 2022-03-15 |
Other References:
SATO MASAHIRO, KAJIKAWA KANTA, KUMON TOMOYA, WATANABE DAISUKE, TAKASE RYUICHI, HASHIMOTO WATARU: "Mutually Beneficial Symbiosis Between Human and Gut-Dominant Bacteroides Species Through Bacterial Assimilation of Host Mucosubstances", BIORXIV, 22 August 2020 (2020-08-22), pages 1 - 31, XP055969901, Retrieved from the Internet [retrieved on 20221011], DOI: 10.1101/2020.08.21.262261
WYLENSEK DAVID, HITCH THOMAS C. A., RIEDEL THOMAS, AFRIZAL AFRIZAL, KUMAR NEERAJ, WORTMANN ESTHER, LIU TIANZHE, DEVENDRAN SARAVANA: "A collection of bacterial isolates from the pig intestine reveals functional and taxonomic diversity", NATURE COMMUNICATIONS, vol. 11, no. 1, 1 December 2020 (2020-12-01), UK, pages 1 - 26, XP055969903, ISSN: 2041-1723, DOI: 10.1038/s41467-020-19929-w
WYLENSEK DAVID, HITCH THOMAS C. A., RIEDEL THOMAS, AFRIZAL AFRIZAL, KUMAR NEERAJ, WORTMANN ESTHER, LIU TIANZHE, DEVENDRAN SARAVANA: "A collection of bacterial isolates from the pig intestine reveals functional and taxonomic diversity", NATURE COMMUNICATIONS, vol. 11, no. 1, 1 December 2020 (2020-12-01), UK, pages 1 - 26, XP055969903, ISSN: 2041-1723, DOI: 10.1038/s41467-020-19929-w
Attorney, Agent or Firm:
MAPS INTELLECTUAL PROPERTY LAW FIRM (KR)
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