METHOD OF DIFFERENTIATING MESENCHYMAL STEM CELL INTO LIVER CELL AND ARTIFICIAL HUMAN LIVER CELL

WIPO Patent Application WO/2005/024004

A1

A liver cell can be hardly established. Therefore, it is intended to provide a means of preparing a liver cell useful in the liver cell transplantation therapy for liver injury which comprises differentiating a mesenchymal stem cell (in particular, a stroma cell, i.e., a bone marrow-origin mesenchymal stem cell) the growth method for which has been already established into a liver cell. It is found out that, by transplanting human mesenchymal stem cells into a mammal suffering from chronic liver injury induced by continuous chemical administration (for example, rat liver), the human mesenchymal stem cells can be differentiated into liver cells or matured liver cells. Thus, a means of differentiating a mesenchymal stem cell into a matured liver cell has been developed.

JP6992983	A composition for the prevention or treatment of inflammatory diseases containing stem cells overexpressing SOD3 as an active ingredient.
JP2005102558	METHOD FOR PROLIFERATING AND INDUCING NERVE STEM CELL
JP2008119002	DEDIFFERENTIATED, PROGRAMMABLE STEM CELL OF MONOCYTIC ORIGIN, AND PRODUCTION AND USE THEREOF

HAMADA HIROFUMI (JP)
NIITSU YOSHIRO (JP)
KATO JUNJI (JP)
SATO YASUSHI (JP)

PCT/JP2004/002440

March 17, 2005

February 27, 2004

Click for automatic bibliography generation  

RENOMEDIX INST INC (JP)
HAMADA HIROFUMI (JP)
NIITSU YOSHIRO (JP)
KATO JUNJI (JP)
SATO YASUSHI (JP)

A61K35/28; A61K35/407; A61P1/16; A61P43/00; C12N5/071; C12N5/10; C12N15/54; (IPC1-7): C12N5/10; A61K35/28; A61K35/407; A61P1/16; A61P43/00; C12N15/54

ALISON M R, ET AL: "Hepatocytes from non-hepatic adult stem cells", NATURE, vol. 406, 2000, pages 257, XP002195493
PETERSEN B E, ET AL: "Bone marrow as a potential source of hepatic oval cells", SCIENCE, vol. 284, 1999, pages 1168 - 1170, XP002147735
TUAN R S, ET AL: "adult mesenchymal stem cells and cell-based tissue engineering", ARTHRITIS RESEARCH AND THERAPY, vol. 5, no. 1, 2002, pages 32 - 45, XP002976496
BARRY F P, ET AL: "Biology and clinical applications of mesenchymal stem cells", BIRTH DEFECTS RESEARH PART C, vol. 69, 25 August 2003 (2003-08-25), pages 250 - 256, XP002976497

Hiraki, Yusuke Fujita Takashi Ishii Sadaji (19F 3-20, Toranomon 4-chom, Minato-ku Tokyo 01, JP)

View/Download PDF      PDF Help

Previous Patent: DEVELOPMENT OF AN ANIONIC SENSOR FOR LIVING CELLS : APPLICATION TO THE HUMAN GLYCINE RECEPTOR

Next Patent: COAGULATION FACTOR VII POLYPEPTIDES