Title:
METHOD OF DIFFERENTIATION OF HUMAN INDUCED PLURIPOTENT STEM CELL TO DERMAL PAPILLA PRECURSOR CELL AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/017691
Kind Code:
A9
Abstract:
The present invention relates to a medium composition for differentiation of a human induced pluripotent stem cell to a dermal papilla precursor cell, a differentiation method, and a use for inducing hair follicle neogenesis using the differentiated dermal papilla precursor cell. The present inventors have developed a method for differentiating a human induced pluripotent stem cell into a dermal papilla precursor cell having hair follicle forming ability and a composition of a dermal papilla precursor cell specific differentiation medium for the above differentiation, and have effectively induced hair follicle neogenesis consisting only of human cells without conventional mouse-human hybrid hair follicles by using the human induced dermal papilla precursor cell and a human induced epidermal precursor cell obtained through the differentiation method. Human hair follicle tissue produced by applying the technique for differentiating the dermal papilla precursor cell according to the present invention is expected to be useful as a therapeutic method for patients suffering from hair loss by overcoming the limitations of hair loss treatments.
Inventors:
KWON OHSANG (KR)
KANG BO MI (KR)
KIM JIN YONG (KR)
KWON YOO-WOOK (KR)
KANG BO MI (KR)
KIM JIN YONG (KR)
KWON YOO-WOOK (KR)
Application Number:
PCT/KR2018/008123
Publication Date:
May 09, 2019
Filing Date:
July 18, 2018
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
C12N5/071
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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