Title:
METHOD FOR DIFFERENTIATION INTO RETINAL CELLS FROM STEM CELLS
Document Type and Number:
WIPO Patent Application WO/2011/043591
Kind Code:
A2
Abstract:
Disclosed is a method for inducing stem cells to differentiate into retinal cells at high yield within a short period of time, without gene implantation and co-culture with retinal tissues, by implementing a differentiation process similar to the in vivo embryonic development in chemically defined conditions. Also, retinal cells including the photoreceptor cells and their progenitor cells, and various types of other retinal cells, generated according to the method, are disclosed. A composition comprising the retinal cells and a method are provided for treating retinal degeneration-related diseases. The differentiated photoreceptor cells, when transplanted into degenerated or injured retinas, can be engrafted and fused within the retinas to prevent or cure retinal degeneration.
Inventors:
KIM JI YEON (KR)
PARK SUNG SUP (KR)
PARK SUNG SUP (KR)
Application Number:
PCT/KR2010/006832
Publication Date:
April 14, 2011
Filing Date:
October 06, 2010
Export Citation:
Assignee:
SNU R&DB FOUNDATION (KR)
KIM JI YEON (KR)
PARK SUNG SUP (KR)
KIM JI YEON (KR)
PARK SUNG SUP (KR)
International Classes:
C12N5/071; C12N5/02; C12N5/07
Foreign References:
| US7541186B2 | 2009-06-02 |
Other References:
D'AMOUR ET AL., NAT. BIOTECHNOL., vol. 24, 2006, pages 1392 - 401
PANKRATZ ET AL., STEM CELLS, vol. 25, 2007, pages 1511 - 20
BARBERI ET AL., NAT. MED., vol. 13, 2007, pages 642 - 8
WANG ET AL., NAT. BIOTECHNOL., vol. 25, 2007, pages 317 - 8
LAMBA, PROC. NATL. ACAD. SCI. USA, vol. 103, 2006, pages 12769 - 74
OSAKADA ET AL., NAT. BIOTECHNOL., vol. 26, 2008, pages 215 - 24
RYAN; GOSS, ONCOLOGIST., vol. 13, 2008, pages 16 - 24
YAMAMOTO; OELGESCHLAGER, NATURWISSENSCHAFTEN, vol. 91, 2004, pages 519 - 34
YANAGITA, CYTOKINE GROWTH FACTOR REV., vol. 16, 2005, pages 309 - 17
BOTTCHER; NIEHRS, ENDOCR REV., vol. 26, 2005, pages 63 - 77
LOGAN; NUSSE, ANNU REV CELL DEV BIOL., vol. 20, 2004, pages 781 - 810
BERTRAND; DAHMANE, TRENDS CELL BIOL, vol. 16, 2006, pages 597 - 605
ZUBER ET AL., DEVELOPMENT, vol. 130, 2003, pages 5155 - 67
KAWANO; KYPTA, J CELL SCI., vol. 116, 2003, pages 2627 - 34
PICCOLO ET AL., NATURE, vol. 397, 1999, pages 707 - 10
BAUMER ET AL., DEVELOPMENT, vol. 130, 2003, pages 2903 - 15
See also references of EP 2486126A4
PANKRATZ ET AL., STEM CELLS, vol. 25, 2007, pages 1511 - 20
BARBERI ET AL., NAT. MED., vol. 13, 2007, pages 642 - 8
WANG ET AL., NAT. BIOTECHNOL., vol. 25, 2007, pages 317 - 8
LAMBA, PROC. NATL. ACAD. SCI. USA, vol. 103, 2006, pages 12769 - 74
OSAKADA ET AL., NAT. BIOTECHNOL., vol. 26, 2008, pages 215 - 24
RYAN; GOSS, ONCOLOGIST., vol. 13, 2008, pages 16 - 24
YAMAMOTO; OELGESCHLAGER, NATURWISSENSCHAFTEN, vol. 91, 2004, pages 519 - 34
YANAGITA, CYTOKINE GROWTH FACTOR REV., vol. 16, 2005, pages 309 - 17
BOTTCHER; NIEHRS, ENDOCR REV., vol. 26, 2005, pages 63 - 77
LOGAN; NUSSE, ANNU REV CELL DEV BIOL., vol. 20, 2004, pages 781 - 810
BERTRAND; DAHMANE, TRENDS CELL BIOL, vol. 16, 2006, pages 597 - 605
ZUBER ET AL., DEVELOPMENT, vol. 130, 2003, pages 5155 - 67
KAWANO; KYPTA, J CELL SCI., vol. 116, 2003, pages 2627 - 34
PICCOLO ET AL., NATURE, vol. 397, 1999, pages 707 - 10
BAUMER ET AL., DEVELOPMENT, vol. 130, 2003, pages 2903 - 15
See also references of EP 2486126A4
Attorney, Agent or Firm:
SON, Min (6th Floor City Air Tower,159-9 Samseong-dong, Gangnam-gu, Seoul 135-973, KR)
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