Title:
METHOD FOR DISCRIMINATION BETWEEN BIPOLAR DISORDER AND SCHIZOPHRENIA
Document Type and Number:
WIPO Patent Application WO/2010/026821
Kind Code:
A1
Abstract:
Disclosed is a novel means which can diagnose schizophrenia and bipolar disorder distinctively, objectively and with high accuracy by using blood collected from a patient as a sample. Specifically disclosed is a method for discriminating between schizophrenia and bipolar disorder, which utilizes the expression levels of specific 12 genes in a sample isolated from a living body as measures. The method enables the distinctive, objective and highly accurate diagnosis of schizophrenia and bipolar disorder. It is confirmed actually by using multiple samples that both the sensitivity (true positive rate) and the degree of specificity (true negative rate) of the detection are 80% or more. The method utilizes blood as a sample, and therefore can be practiced conveniently.
Inventors:
AOSHIMA HIDEYUKI (JP)
TAKEMURA KAZUO (JP)
IIJIMA KENTARO (JP)
HAYASHI HIROSHI (JP)
TAKEMURA KAZUO (JP)
IIJIMA KENTARO (JP)
HAYASHI HIROSHI (JP)
Application Number:
PCT/JP2009/061158
Publication Date:
March 11, 2010
Filing Date:
June 19, 2009
Export Citation:
Assignee:
SRL INC (JP)
AOSHIMA HIDEYUKI (JP)
TAKEMURA KAZUO (JP)
IIJIMA KENTARO (JP)
HAYASHI HIROSHI (JP)
AOSHIMA HIDEYUKI (JP)
TAKEMURA KAZUO (JP)
IIJIMA KENTARO (JP)
HAYASHI HIROSHI (JP)
International Classes:
C12Q1/68; C12N15/09
Domestic Patent References:
| WO2003039490A2 | 2003-05-15 | |||
| WO2006105516A2 | 2006-10-05 | |||
| WO2007059064A2 | 2007-05-24 |
Foreign References:
| JP2007528704A | 2007-10-18 |
Other References:
AKINARI ITOKAWA ET AL.: "Togo Shicchosho - Kibun Shogai to Idenshi", SEISHINKA, vol. 11, no. 3, 2007, pages 187 - 195
HIROAKI TOMITA: "Kibun Shogai no Morateki Idenshi Hatsugen Kaiseki", IGAKU NO AYUMI, vol. 9, no. 3, 22 April 2009 (2009-04-22), pages 182 - 186
TADAO ARINAMI: "Togo Shicchosho no Iden Kaiseki", JAPANESE JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, vol. 10, no. 5, 2007, pages 869 - 883
TETSURO OMORI ET AL.: "DNA Microarray ni yoru Utsubyo no Atarashii Shindan Marker", PSYCHIATRIA ET NEUROLOGIA JAPONICA, vol. 108, no. 6, 2006, pages 642 - 645
HIROAKI TOMITA: "Kibun Shogai no Morateki Idenshi Hatsugen Kaiseki", IGAKU NO AYUMI, vol. 9, no. 3, 22 April 2009 (2009-04-22), pages 182 - 186
TADAO ARINAMI: "Togo Shicchosho no Iden Kaiseki", JAPANESE JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, vol. 10, no. 5, 2007, pages 869 - 883
TETSURO OMORI ET AL.: "DNA Microarray ni yoru Utsubyo no Atarashii Shindan Marker", PSYCHIATRIA ET NEUROLOGIA JAPONICA, vol. 108, no. 6, 2006, pages 642 - 645
Attorney, Agent or Firm:
TANIGAWA, Hidejiro (JP)
Mountain stream Eijiro (JP)
Mountain stream Eijiro (JP)
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