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Title:
METHOD FOR DISCRIMINATION BETWEEN BIPOLAR DISORDER AND SCHIZOPHRENIA
Document Type and Number:
WIPO Patent Application WO/2010/026821
Kind Code:
A1
Abstract:
Disclosed is a novel means which can diagnose schizophrenia and bipolar disorder distinctively, objectively and with high accuracy by using blood collected from a patient as a sample.  Specifically disclosed is a method for discriminating between schizophrenia and bipolar disorder, which utilizes the expression levels of specific 12 genes in a sample isolated from a living body as measures.  The method enables the distinctive, objective and highly accurate diagnosis of schizophrenia and bipolar disorder.  It is confirmed actually by using multiple samples that both the sensitivity (true positive rate) and the degree of specificity (true negative rate) of the detection are 80% or more.  The method utilizes blood as a sample, and therefore can be practiced conveniently.

Inventors:
AOSHIMA, Hideyuki (51 Komiyamachi Hachioji-sh, Tokyo 35, 〒1928535, JP)
青島 秀幸 (〒35 東京都八王子市小宮町51 株式会社エスアールエル八王子ラボラトリー内 Tokyo, 〒1928535, JP)
TAKEMURA, Kazuo (51 Komiyamachi Hachioji-sh, Tokyo 35, 〒1928535, JP)
竹村 一男 (〒35 東京都八王子市小宮町51 株式会社エスアールエル八王子ラボラトリー内 Tokyo, 〒1928535, JP)
Application Number:
JP2009/061158
Publication Date:
March 11, 2010
Filing Date:
June 19, 2009
Export Citation:
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Assignee:
SRL, INC. (41-19, Akebonocho 2-chome Tachikawa-sh, Tokyo 67, 〒1908567, JP)
株式会社エスアールエル (〒67 東京都立川市曙町二丁目41番19号 Tokyo, 〒1908567, JP)
AOSHIMA, Hideyuki (51 Komiyamachi Hachioji-sh, Tokyo 35, 〒1928535, JP)
青島 秀幸 (〒35 東京都八王子市小宮町51 株式会社エスアールエル八王子ラボラトリー内 Tokyo, 〒1928535, JP)
TAKEMURA, Kazuo (51 Komiyamachi Hachioji-sh, Tokyo 35, 〒1928535, JP)
International Classes:
C12Q1/68; C12N15/09
Domestic Patent References:
WO2003039490A2
WO2006105516A2
WO2007059064A2
Foreign References:
JP2007528704A
Other References:
AKINARI ITOKAWA ET AL.: 'Togo Shicchosho - Kibun Shogai to Idenshi' SEISHINKA vol. 11, no. 3, 2007, pages 187 - 195
HIROAKI TOMITA: 'Kibun Shogai no Morateki Idenshi Hatsugen Kaiseki' IGAKU NO AYUMI vol. 9, no. 3, 22 April 2009, pages 182 - 186
TADAO ARINAMI: 'Togo Shicchosho no Iden Kaiseki' JAPANESE JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY vol. 10, no. 5, 2007, pages 869 - 883
TETSURO OMORI ET AL.: 'DNA Microarray ni yoru Utsubyo no Atarashii Shindan Marker' PSYCHIATRIA ET NEUROLOGIA JAPONICA vol. 108, no. 6, 2006, pages 642 - 645
Attorney, Agent or Firm:
TANIGAWA, Hidejiro (Patent Firm 6F, SK Iidabashi Bldg., 5-12, Iidabashi 4-chome, Chiyoda-k, Tokyo 72, 〒1020072, JP)
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