Title:
METHOD FOR DISTINGUISHING AML SUBTYPE INV(3)(q21q26)/t(3;3)(q21q26) FROM OTHER AML SUBTYPES
Document Type and Number:
WIPO Patent Application WO2005045438
Kind Code:
A3
Abstract:
Disclosed is a method for distinguishing AML subtype AML_inv(3) from other AML subtypes in a sample by determining the expression level of markers, as well as a diagnostic kit and an apparatus containing the markers.
Inventors:
HAFERLACH TORSTEN (DE)
DUGAS MARTIN (DE)
KERN WOLFGANG (DE)
KOHLMANN ALEXANDER (DE)
SCHNITTGER SUSANNE (DE)
SCHOCH CLAUDIA (DE)
DUGAS MARTIN (DE)
KERN WOLFGANG (DE)
KOHLMANN ALEXANDER (DE)
SCHNITTGER SUSANNE (DE)
SCHOCH CLAUDIA (DE)
Application Number:
PCT/EP2004/012461
Publication Date:
August 11, 2005
Filing Date:
November 04, 2004
Export Citation:
Assignee:
ROCHE DIAGNOSTICS GMBH (DE)
HOFFMANN LA ROCHE (CH)
HAFERLACH TORSTEN (DE)
DUGAS MARTIN (DE)
KERN WOLFGANG (DE)
KOHLMANN ALEXANDER (DE)
SCHNITTGER SUSANNE (DE)
SCHOCH CLAUDIA (DE)
HOFFMANN LA ROCHE (CH)
HAFERLACH TORSTEN (DE)
DUGAS MARTIN (DE)
KERN WOLFGANG (DE)
KOHLMANN ALEXANDER (DE)
SCHNITTGER SUSANNE (DE)
SCHOCH CLAUDIA (DE)
International Classes:
C12Q1/68; G01N33/574; (IPC1-7): G01N33/574; C12Q1/68
Domestic Patent References:
| WO2003039443A2 | 2003-05-15 |
Foreign References:
| EP1308522A1 | 2003-05-07 | |||
| EP1043676A2 | 2000-10-11 |
Other References:
SCHOCH CLAUDIA ET AL: "Acute myeloid leukemias with reciprocal rearrangements can be distinguished by specific gene expression profiles", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 99, no. 15, 23 July 2002 (2002-07-23), pages 10008 - 10013, XP002215484, ISSN: 0027-8424
KOHLMANN A ET AL: "MOLECULAR CHARACTERIZATION OF ACUTE LEUKEMIAS BY USE OF MICROARRAY TECHNOLOGY", GENES, CHROMOSOMES & CANCER, XX, XX, vol. 37, no. 4, August 2003 (2003-08-01), pages 396 - 405, XP008025253
SOOD R ET AL: "MDS1/EVI1 enhances TGF-beta1 signaling and strengthens its growth-inhibitory effect, but the leukemia-associated fusion protein AML1/MDS1/EVI1, product of the t(3;21), abrogates growth-inhibition in response to TGF-beta1", LEUKEMIA (BASINGSTOKE), vol. 13, no. 3, March 1999 (1999-03-01), pages 348 - 357, XP002274829, ISSN: 0887-6924
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2002 (2002-11-16), KOHLMANN ALEXANDER ET AL: "Gene Expression Profiles of t(11q23)/MLL Positive ALL and AML.", XP002269818, Database accession no. PREV200300356357
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2001 (2001-11-16), SCHOCH CLAUDIA ET AL: "Specific abnormalities on the genomic level result in a distinct gene expression pattern detected by oligonucleotide microarrays: An analysis of 25 patients with AML M2/t(8;21), AML M3/M3v/t(15;17), and AML M4eo/inv(16)", XP002269491, Database accession no. PREV200200129822
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2002 (2002-11-16), SCHOCH CLAUDIA ET AL: "AML with Complex Aberrant Karyotype Can Be Distinguished from All Other AML Subtypes by Gene Expression Profiles and Are Characterized by Higher Expression of Genes Involved in DNA Repair.", XP002269820, Database accession no. PREV200300335804
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2002 (2002-11-16), KOHLMANN ALEXANDER ET AL: "A Gene Expression Study of 59 Acute Myeloid Leukemia (AML) Patients with Recurrent Cytogenetic Abnormalities.", XP002269490, Database accession no. PREV200300335805
GOLUB T R ET AL: "Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 286, no. 5439, 15 October 1999 (1999-10-15), pages 531 - 537, XP002207658, ISSN: 0036-8075
DUGAS M ET AL: "A comprehensive leukemia database: integration of cytogenetics, molecular genetics and microarray data with clinical information, cytomorphology and immunophenotyping", LEUKEMIA, MACMILLAN PRESS LTD, US, vol. 15, no. 12, December 2001 (2001-12-01), pages 1805 - 1810, XP002263731, ISSN: 0887-6924
DUGAS MARTIN ET AL: "Impact of integrating clinical and genetic information.", IN SILICO BIOLOGY, vol. 2, no. 3, 2002, pages 383 - 391, XP001179418, ISSN: 1386-6338 (ISSN print)
DEUTSCH J M: "Evolutionary algorithms for finding optimal gene sets in microarray prediction.", BIOINFORMATICS (OXFORD), vol. 19, no. 1, January 2003 (2003-01-01), pages 45 - 52, XP002272405, ISSN: 1367-4803
ALIZADEH A ET AL: "THE LYMPHOCHIP: A SPECIALIZED CDNA MICROARRAY FOR THE GENOMIC-SCALE ANALYSIS OF GENE EXPRESSION IN NORMAL AND MALIGNANT LYMPHOCYTES", COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, BIOLOGICAL LABORATORY, COLD SPRING HARBOR, NY, US, vol. 64, no. 1, 1999, pages 71 - 78, XP001099007, ISSN: 0091-7451
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2002 (2002-11-16), SCHNITTGER SUSANNE ET AL: "Networks of Molecular Mutations in Acute Myeloid Leukemia and Their Correlations to Cytogenetics and Morphology.", XP002272705, Database accession no. PREV200300357666
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2002 (2002-11-16), KOHLMANN ALEXANDER ET AL: "A Simplified and Partially Automated Target Preparation Method for Gene Expression Profiling.", XP002269495, Database accession no. PREV200300367771
WIESER ROTRAUD ET AL: "Masked inv(3)(q21q26) in a patient with minimally differentiated acute myeloid leukemia", HAEMATOLOGICA, vol. 86, no. 2, February 2001 (2001-02-01), pages 214 - 215, XP002274830, ISSN: 0390-6078
KOHLMANN A ET AL: "MOLECULAR CHARACTERIZATION OF ACUTE LEUKEMIAS BY USE OF MICROARRAY TECHNOLOGY", GENES, CHROMOSOMES & CANCER, XX, XX, vol. 37, no. 4, August 2003 (2003-08-01), pages 396 - 405, XP008025253
SOOD R ET AL: "MDS1/EVI1 enhances TGF-beta1 signaling and strengthens its growth-inhibitory effect, but the leukemia-associated fusion protein AML1/MDS1/EVI1, product of the t(3;21), abrogates growth-inhibition in response to TGF-beta1", LEUKEMIA (BASINGSTOKE), vol. 13, no. 3, March 1999 (1999-03-01), pages 348 - 357, XP002274829, ISSN: 0887-6924
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2002 (2002-11-16), KOHLMANN ALEXANDER ET AL: "Gene Expression Profiles of t(11q23)/MLL Positive ALL and AML.", XP002269818, Database accession no. PREV200300356357
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2001 (2001-11-16), SCHOCH CLAUDIA ET AL: "Specific abnormalities on the genomic level result in a distinct gene expression pattern detected by oligonucleotide microarrays: An analysis of 25 patients with AML M2/t(8;21), AML M3/M3v/t(15;17), and AML M4eo/inv(16)", XP002269491, Database accession no. PREV200200129822
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2002 (2002-11-16), SCHOCH CLAUDIA ET AL: "AML with Complex Aberrant Karyotype Can Be Distinguished from All Other AML Subtypes by Gene Expression Profiles and Are Characterized by Higher Expression of Genes Involved in DNA Repair.", XP002269820, Database accession no. PREV200300335804
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2002 (2002-11-16), KOHLMANN ALEXANDER ET AL: "A Gene Expression Study of 59 Acute Myeloid Leukemia (AML) Patients with Recurrent Cytogenetic Abnormalities.", XP002269490, Database accession no. PREV200300335805
GOLUB T R ET AL: "Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 286, no. 5439, 15 October 1999 (1999-10-15), pages 531 - 537, XP002207658, ISSN: 0036-8075
DUGAS M ET AL: "A comprehensive leukemia database: integration of cytogenetics, molecular genetics and microarray data with clinical information, cytomorphology and immunophenotyping", LEUKEMIA, MACMILLAN PRESS LTD, US, vol. 15, no. 12, December 2001 (2001-12-01), pages 1805 - 1810, XP002263731, ISSN: 0887-6924
DUGAS MARTIN ET AL: "Impact of integrating clinical and genetic information.", IN SILICO BIOLOGY, vol. 2, no. 3, 2002, pages 383 - 391, XP001179418, ISSN: 1386-6338 (ISSN print)
DEUTSCH J M: "Evolutionary algorithms for finding optimal gene sets in microarray prediction.", BIOINFORMATICS (OXFORD), vol. 19, no. 1, January 2003 (2003-01-01), pages 45 - 52, XP002272405, ISSN: 1367-4803
ALIZADEH A ET AL: "THE LYMPHOCHIP: A SPECIALIZED CDNA MICROARRAY FOR THE GENOMIC-SCALE ANALYSIS OF GENE EXPRESSION IN NORMAL AND MALIGNANT LYMPHOCYTES", COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, BIOLOGICAL LABORATORY, COLD SPRING HARBOR, NY, US, vol. 64, no. 1, 1999, pages 71 - 78, XP001099007, ISSN: 0091-7451
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2002 (2002-11-16), SCHNITTGER SUSANNE ET AL: "Networks of Molecular Mutations in Acute Myeloid Leukemia and Their Correlations to Cytogenetics and Morphology.", XP002272705, Database accession no. PREV200300357666
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2002 (2002-11-16), KOHLMANN ALEXANDER ET AL: "A Simplified and Partially Automated Target Preparation Method for Gene Expression Profiling.", XP002269495, Database accession no. PREV200300367771
WIESER ROTRAUD ET AL: "Masked inv(3)(q21q26) in a patient with minimally differentiated acute myeloid leukemia", HAEMATOLOGICA, vol. 86, no. 2, February 2001 (2001-02-01), pages 214 - 215, XP002274830, ISSN: 0390-6078
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