Title:
METHOD FOR DISTINGUISHING BETWEEN MULTIPLE SCLEROSIS AND NEUROMYELITIS OPTICA SPECTRUM DISORDER
Document Type and Number:
WIPO Patent Application WO/2019/009446
Kind Code:
A1
Abstract:
The present invention relates to a composition for distinguishing between multiple sclerosis and neuromyelitis optica spectrum disorder, and a method for distinguishing between multiple sclerosis and neuromyelitis optica spectrum disorder using the composition. Specifically, the method of the present invention may clearly distinguish between multiple sclerosis and neuromyelitis optica spectrum disorder which have similar clinical features by measuring the concentrations of citric acid and lactic acid which are specific metabolites in cerebrospinal fluid and comparing said concentrations with the concentrations of citric acid and lactic acid in normal subjects, and therefore may be usefully used to diagnose multiple sclerosis and neuromyelitis optica spectrum disorder.
Inventors:
PARK SUNG JEAN (KR)
KIM HO JIN (KR)
KIM HYUN HWI (KR)
KIM HO JIN (KR)
KIM HYUN HWI (KR)
Application Number:
PCT/KR2017/007193
Publication Date:
January 10, 2019
Filing Date:
July 05, 2017
Export Citation:
Assignee:
UNIV GACHON IND ACAD COOP FOUND (KR)
International Classes:
G01N33/48; G01N33/53
Domestic Patent References:
| WO2007137410A1 | 2007-12-06 |
Other References:
JEONG, I.: "Metabolomic profiling of multiple sclerosis and neuromyelitis optica spectrum disorder by nuclear magnetic resonance (P4.146", NEUROLOGY, vol. 86, 19 April 2016 (2016-04-19), pages 16
PARK, S. J.: "Disease type-and status-specific alteration of CSF metabolome coordinated with clinical parameters in inflammatory demyelinating diseases of CNS", PLOS ONE, vol. 11, no. 11, 17 November 2016 (2016-11-17), pages 1 - 15, XP055680089, DOI: 10.1371/journal.pone.0166277
GEBREGIWORGIS, T.: "A urinary metabolic signature for multiple sclerosis and neuromyelitis optica", JOURNAL OF PROTEOME RESEARCH, vol. 15, no. 2, 13 January 2016 (2016-01-13), pages 659 - 666, XP055680091, ISSN: 1535-3893, DOI: 10.1021/acs.jproteome.5b01111
CHEN, H.: "Clinical features of patients with multiple sclerosis and neuromyelitis optica spectrum disorders", CHINESE MEDICAL JOURNAL, vol. 129, no. 17, 5 September 2016 (2016-09-05), pages 2079 - 2084, XP055680097, DOI: 10.4103/0366‑6999.189046
PARK, S. J.: "Disease type-and status-specific alteration of CSF metabolome coordinated with clinical parameters in inflammatory demyelinating diseases of CNS", PLOS ONE, vol. 11, no. 11, 17 November 2016 (2016-11-17), pages 1 - 15, XP055680089, DOI: 10.1371/journal.pone.0166277
GEBREGIWORGIS, T.: "A urinary metabolic signature for multiple sclerosis and neuromyelitis optica", JOURNAL OF PROTEOME RESEARCH, vol. 15, no. 2, 13 January 2016 (2016-01-13), pages 659 - 666, XP055680091, ISSN: 1535-3893, DOI: 10.1021/acs.jproteome.5b01111
CHEN, H.: "Clinical features of patients with multiple sclerosis and neuromyelitis optica spectrum disorders", CHINESE MEDICAL JOURNAL, vol. 129, no. 17, 5 September 2016 (2016-09-05), pages 2079 - 2084, XP055680097, DOI: 10.4103/0366‑6999.189046
Attorney, Agent or Firm:
LEE, Won Hee (KR)
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