Title:
METHOD OF EFFICIENTLY MODIFYING SURFACE OF BACTERIUM
Document Type and Number:
WIPO Patent Application WO/2005/095428
Kind Code:
A1
Abstract:
A bacterium having a functional substance on the surface; and a process for producing the bacterium. In particular, a bacterium such as, e.g., one which enhances intestinal absorption, is produced. Also provided is a compound represented by the general formula (I): wherein R1, R2, and R3 each independently is hydrogen or a protective group; R4 is hydrogen, optionally substituted acetyl, optionally substituted monophosphate, optionally substituted diphosphate, or optionally substituted triphosphate; W is -(C=O)-CH2-, -C≡C-, or a group imparting a function; X is a single bond or -(CH2)n-; n is an integer of 1 to 10; and Y is -(C=O)-R8 (wherein R8 is alkyl), -C≡CH, or a group imparting a function.
Inventors:
NISHIMURA SHINICHIRO (JP)
SADAMOTO REIKO (JP)
UEDA TAICHI (JP)
NIIKURA KENICHI (JP)
SADAMOTO REIKO (JP)
UEDA TAICHI (JP)
NIIKURA KENICHI (JP)
Application Number:
PCT/JP2005/005945
Publication Date:
October 13, 2005
Filing Date:
March 29, 2005
Export Citation:
Assignee:
SHIONOGI & CO (JP)
NISHIMURA SHINICHIRO (JP)
SADAMOTO REIKO (JP)
UEDA TAICHI (JP)
NIIKURA KENICHI (JP)
NISHIMURA SHINICHIRO (JP)
SADAMOTO REIKO (JP)
UEDA TAICHI (JP)
NIIKURA KENICHI (JP)
International Classes:
A23L1/30; C07H11/04; C07H13/06; C12N1/20; C12N1/38; (IPC1-7): C07H11/04; C07H13/06; C12N1/20
Foreign References:
| JP2003125758A | 2003-05-07 |
Other References:
VOCADLO D. ET AL.: "A chemical approach for indentifying O-GlcNAc-modified proteins in cells.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA., vol. 100, no. 16, 2003, pages 9116 - 9121, XP002987353
SAXON E. ET AL.: "Investigating Cellular Metabolism of Synthetic Azidosugars with the Staudinger Ligation.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 124, no. 50, 2002, pages 14893 - 14902, XP002987354
KISO M. ET AL.: "Application of ferric chloride-catalyzed glycosylation to a synthesis of glycolipids.", CARBOHYDRATE RESEARCH., vol. 81, 1980, pages 13 - 15, XP002986934
SADAMOTO R. ET AL.: "Cell Wall Engineering of living Bacteria through Biosynthesis.", METHODS IN ENZYMOLOGY., vol. 362, 2003, pages 273 - 286, XP002974355
SADAMOTO R. ET AL.: "Control of Bacteria Adhesion by Cell-Wall Engineering.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 126, no. 12, 2004, pages 3755 - 3761, XP008035406
SAXON E. ET AL.: "Investigating Cellular Metabolism of Synthetic Azidosugars with the Staudinger Ligation.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 124, no. 50, 2002, pages 14893 - 14902, XP002987354
KISO M. ET AL.: "Application of ferric chloride-catalyzed glycosylation to a synthesis of glycolipids.", CARBOHYDRATE RESEARCH., vol. 81, 1980, pages 13 - 15, XP002986934
SADAMOTO R. ET AL.: "Cell Wall Engineering of living Bacteria through Biosynthesis.", METHODS IN ENZYMOLOGY., vol. 362, 2003, pages 273 - 286, XP002974355
SADAMOTO R. ET AL.: "Control of Bacteria Adhesion by Cell-Wall Engineering.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 126, no. 12, 2004, pages 3755 - 3761, XP008035406
Attorney, Agent or Firm:
Yamamoto, Shusaku (Crystal Tower 2-27, Shiromi 1-chome, Chuo-ku, Osaka-sh, Osaka 15, JP)
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