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Patent Searching and Data


Title:
METHOD OF ENGINEERING MICROORGANISMS FOR THE OVERPRODUCTION OF SHORT BRANCHED-CHAIN FATTY ACIDS
Document Type and Number:
WIPO Patent Application WO/2018/067068
Kind Code:
A8
Abstract:
The present invention relates to methods of metabolic engineering to increase the levels of short branched-chain fatty acids (SBCFAs) produced by microorganisms such as yeast. More particularly, the invention provides methods to engineer Saccharomyces cerevisiae to overexpress Ehrlich pathway genes, inhibit at least one alcohol dehydrogenase and enhance secretion of the produced SBCFAs, and also provides recombinant cells produced by such methods.

Inventors:
CHANG MATTHEW WOOK (SG)
YU AI-QUN (SG)
PRATOMO JUWONO NINA KURNIASIH (SG)
Application Number:
PCT/SG2017/050490
Publication Date:
May 24, 2018
Filing Date:
September 29, 2017
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Assignee:
NAT UNIV SINGAPORE (SG)
International Classes:
C12N1/19; C12N15/81; C12P7/40
Attorney, Agent or Firm:
MATTEUCCI, Gianfranco (SG)
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