Title:
METHOD FOR ENHANCING ANTI-TUMOR FUNCTION OF T LYMPHOCYTE AND USE
Document Type and Number:
WIPO Patent Application WO/2024/066115
Kind Code:
A1
Abstract:
Disclosed are a method for enhancing the anti-tumor function of a T lymphocyte and use. The method comprises the step of culturing a T lymphocyte under a physical electrical stimulation condition, wherein the T lymphocyte comprises an initial T cell or a modified T lymphocyte. The method does not involve complex traditional gene editing means with lengthy screening processes, can rapidly and effectively enhance the anti-tumor function of the T lymphocyte, and can be used for promoting CAR-T cell therapy.
Inventors:
ZHANG XUEHUI (CN)
DENG XULIANG (CN)
LV DAN (CN)
SONG JIA (CN)
DENG XULIANG (CN)
LV DAN (CN)
SONG JIA (CN)
Application Number:
PCT/CN2022/143783
Publication Date:
April 04, 2024
Filing Date:
December 30, 2022
Export Citation:
Assignee:
UNIV PEKING SCHOOL STOMATOLOGY (CN)
International Classes:
C12N5/0783; A61K35/17; A61K39/00; C12N5/10; C12N13/00
Foreign References:
| CN101302491A | 2008-11-12 | |||
| CN115261321A | 2022-11-01 |
Other References:
SWAIN SUBHASMITA, PADHY RABINDRA NATH, RAUTRAY TAPASH RANJAN: "Electrically stimulated hydroxyapatite-barium titanate composites demonstrate immunocompatibility in vitro.", JOURNAL OF THE KOREAN CERAMIC SOCIETY, SPRINGER SINGAPORE, SINGAPORE, vol. 57, no. 5, 21 April 2020 (2020-04-21), Singapore, pages 495 - 502, XP009553427, ISSN: 1229-7801, DOI: 10.1007/s43207-020-00048-7
LI YIPING, DAI XIAO-HAN; TANG ZHAN-GUI; ZHANG XUE-HUI: "Effect of BaTO3/P (VDF-TrFE) Nanocomposite Membrane on Proliferation and Proliferation of Stem Cells", JOURNAL OF ORAL SCIENCE RESEARCH, vol. 34, no. 1, 31 January 2018 (2018-01-31), pages 6 - 9, XP093151496, ISSN: 1671-7651, DOI: 10.13701/j.cnki.kqyxyj.2018.01.002
HUANG DENGGAO, GAO YUANHUI; CAO HUI; ZHENG LINLIN; WEN XIAOHONG; FU XIANXIAN; ZHANG SHUFANG: "Enhancement of Proliferation And Anti-Tumor Activity of Human Peripheral Blood Lymphocytes by Low-Intensity Pulsed Ultrasound: A Experimental Study", JOURNAL OF CLINICAL ULTRASOUND IN MEDICINE, vol. 22, no. 1, 31 January 2020 (2020-01-31), XP093151499, ISSN: 1008-6978, DOI: 10.16245/j.cnki.issn1008-6978.2020.01.001
MIE YAN, SUN CAIXIN, YAO CHENGUO, XIONG LAN, WANG SHIBIN, LUO XIAODONG, HU LINA: "Effect of Steep Pulsed Electric Fields on the Immune Response of Tumor-bearing Wistar Mice", JOURNAL OF BIOMEDICAL ENGINEERING, vol. 24, no. 2, 31 December 2007 (2007-12-31), pages 253 - 256, XP093151503
ARNOLD CHRISTINA E., RAJNICEK ANN M., HOARE JOSEPH I., POKHAREL SWECHHA MAINALI, MCCAIG COLIN D., BARKER ROBERT N., WILSON HEATHER: "Physiological strength electric fields modulate human T cell activation and polarisation", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 9, no. 1, US , XP093151505, ISSN: 2045-2322, DOI: 10.1038/s41598-019-53898-5
TANG YUFEI; CHEN LEI; DUAN ZIHAO; ZHAO KANG; WU ZIXIANG: "Graphene/barium titanate/polymethyl methacrylate bio-piezoelectric composites for biomedical application", CERAMICS INTERNATIONAL, ELSEVIER, AMSTERDAM., NL, vol. 46, no. 5, 18 November 2019 (2019-11-18), NL , pages 6567 - 6574, XP086002202, ISSN: 0272-8842, DOI: 10.1016/j.ceramint.2019.11.142
LI YIPING, DAI XIAO-HAN; TANG ZHAN-GUI; ZHANG XUE-HUI: "Effect of BaTO3/P (VDF-TrFE) Nanocomposite Membrane on Proliferation and Proliferation of Stem Cells", JOURNAL OF ORAL SCIENCE RESEARCH, vol. 34, no. 1, 31 January 2018 (2018-01-31), pages 6 - 9, XP093151496, ISSN: 1671-7651, DOI: 10.13701/j.cnki.kqyxyj.2018.01.002
HUANG DENGGAO, GAO YUANHUI; CAO HUI; ZHENG LINLIN; WEN XIAOHONG; FU XIANXIAN; ZHANG SHUFANG: "Enhancement of Proliferation And Anti-Tumor Activity of Human Peripheral Blood Lymphocytes by Low-Intensity Pulsed Ultrasound: A Experimental Study", JOURNAL OF CLINICAL ULTRASOUND IN MEDICINE, vol. 22, no. 1, 31 January 2020 (2020-01-31), XP093151499, ISSN: 1008-6978, DOI: 10.16245/j.cnki.issn1008-6978.2020.01.001
MIE YAN, SUN CAIXIN, YAO CHENGUO, XIONG LAN, WANG SHIBIN, LUO XIAODONG, HU LINA: "Effect of Steep Pulsed Electric Fields on the Immune Response of Tumor-bearing Wistar Mice", JOURNAL OF BIOMEDICAL ENGINEERING, vol. 24, no. 2, 31 December 2007 (2007-12-31), pages 253 - 256, XP093151503
ARNOLD CHRISTINA E., RAJNICEK ANN M., HOARE JOSEPH I., POKHAREL SWECHHA MAINALI, MCCAIG COLIN D., BARKER ROBERT N., WILSON HEATHER: "Physiological strength electric fields modulate human T cell activation and polarisation", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 9, no. 1, US , XP093151505, ISSN: 2045-2322, DOI: 10.1038/s41598-019-53898-5
TANG YUFEI; CHEN LEI; DUAN ZIHAO; ZHAO KANG; WU ZIXIANG: "Graphene/barium titanate/polymethyl methacrylate bio-piezoelectric composites for biomedical application", CERAMICS INTERNATIONAL, ELSEVIER, AMSTERDAM., NL, vol. 46, no. 5, 18 November 2019 (2019-11-18), NL , pages 6567 - 6574, XP086002202, ISSN: 0272-8842, DOI: 10.1016/j.ceramint.2019.11.142
Attorney, Agent or Firm:
BEIJING ZERORICH IP FIRM (CN)
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