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Title:
METHOD FOR ENHANCING LEARNING AND MEMORY IMPAIRED BY NEURODEGENERATIVE DISORDERS AND COMPOUNDS AND COMPOSITIONS FOR EFFECTING THE SAME
Document Type and Number:
WIPO Patent Application WO/2011/133226
Kind Code:
A3
Abstract:
A method for enhancing learning or memory of both in a mammal having impaired learning or emory of both from a neuro-degenerative disorder, which entails the step of administering at least one compound or a salt thereof which is a βι-adrenergic receptor agonist, partial agonist or receptor ligand in an amount effective to improve the learning or memory or both of said mammal.

Inventors:
SHAMLOO, Mehrdad (1705 El Camino Real, Palo Alto, CA, 94306, US)
FAIZI, Mehrdad (1705 El Camino Real, Palo Alto, CA, 94306, US)
MOBLEY, William (1705 El Camino Real, Palo Alto, CA, 94306, US)
Application Number:
US2011/000722
Publication Date:
February 02, 2012
Filing Date:
April 22, 2011
Export Citation:
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Assignee:
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (())
SHAMLOO, Mehrdad (1705 El Camino Real, Palo Alto, CA, 94306, US)
FAIZI, Mehrdad (1705 El Camino Real, Palo Alto, CA, 94306, US)
MOBLEY, William (1705 El Camino Real, Palo Alto, CA, 94306, US)
International Classes:
C12N5/07; C12N5/16
Foreign References:
US20030216413A12003-11-20
US20100130566A12010-05-27
Other References:
SALEHI ET AL.: 'Restoration of norepinephrine-modulaed contextual memory in a mouse model of Down syndrome' SCIENCE TRANSLATIONAL MEDICINE vol. 1, no. ISS.7, 2009,
DIERSSEN ET AL.: 'Alterations of central noradrengeric transmission in Ts65Dn mouse, a model for Down syndrome.' BRAIN RESEARCH vol. 749, 1997, pages 238 - 244
MURCHISON ET AL.: 'A distinct role for norepinephrine in memory retrieval.' CELL vol. 117, 2004, pages 131 - 143
Attorney, Agent or Firm:
BEAUMONT, William, E. (Juneau Partners, 333 N. Fairfax St. Suite 30, Alexandria VA, 22314, US)
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