Title:
METHOD FOR ENHANCING SUSTAINED RELEASE CAPABILITY OF NUCLEIC ACID DRUG
Document Type and Number:
WIPO Patent Application WO/2023/011360
Kind Code:
A1
Abstract:
The present invention relates to a method for enhancing the sustained release capability of a nucleic acid drug. The method comprises: adding the DNA or RNA of a specific sequence to the 5' end and/or the 3' end of the nucleic acid drug and/or inside same. The enhancing of the sustained release capability of a nucleic acid drug refers to delaying the in-vivo sustained release time of a nucleic acid drug and increasing the effective action time thereof in-vivo. The DNA or RNA of the specific sequence is a G-4 chain, and the structure of the G-4 chain contains: Gx1Ny1Gx2Ny2Gx3Ny3Gx4.
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Inventors:
SONG XU (CN)
ZHAO YONGYUN (CN)
YUAN DEYU (CN)
ZHANG XIAOXIA (CN)
ZENG MIAO (CN)
ZHAO YONGYUN (CN)
YUAN DEYU (CN)
ZHANG XIAOXIA (CN)
ZENG MIAO (CN)
Application Number:
PCT/CN2022/109084
Publication Date:
February 09, 2023
Filing Date:
July 29, 2022
Export Citation:
Assignee:
LNCTAC CO LTD (CN)
International Classes:
A61K47/54; A61K31/7088; A61K31/713
Domestic Patent References:
| WO2017188898A1 | 2017-11-02 | |||
| WO2009148605A2 | 2009-12-10 | |||
| WO2015153975A1 | 2015-10-08 |
Other References:
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OBERHAUSER ET AL., NUCL. ACIDS RES., vol. 20, 1992, pages 533 - 538
SAISON-BEHMOARAS ET AL., EMBO J, vol. 10, 1991, pages 1111 - 1118
SVINARCHUK ET AL., BIOCHIMIE, vol. 75, 1993, pages 49 - 54
MANOHARAN ET AL., TETRAHEDRON LETT, vol. 36, 1995, pages 3651 - 3654
SHEA ET AL., NUCL. ACIDS RES., vol. 18, 1990, pages 3777 - 3783
MANOHARAN ET AL., NUCLEOSIDES & NUCLEOTIDES, vol. 14, 1995, pages 969 - 973
MISHRA ET AL., BIOCHIM. BIOPHYS. ACTA, vol. 1264, 1995, pages 229 - 237
CROOKE ET AL., J. PHARMACOL. EXP. THER., vol. 277, 1996, pages 923 - 937
ZAHLER, A.M.WILLIAMSON, J.R.CECH, T.R.PRESCOTT. D.M.: "Suppression of Telomerase by G-quarter DMA Structures", NATURE, vol. 350, 1991, pages 718 - 720
PARKINSON G NLEE M P HNEIDLE S: "Crystal structure of parallel quadruplexes from human telomeric DNA", NATURE, vol. 417, no. 6891, 2002, pages 876 - 880, XP002979541, DOI: 10.1038/nature755
WANG YPATEL D J: "Solution structure of the human telomeric repeat d[AG3(T2AG3)3] G-tetraplex", STRUCTURE, vol. 1, no. 4, 1993, pages 263 - 282, XP024247899, DOI: 10.1016/0969-2126(93)90015-9
DAI J.CARVER M.YANG D: "Polymorphism of human telonieric quadruples structures", BIOCHIMIE, vol. 90, no. 8, 2008, pages 1172 - 1183
SINGH ET AL., CHEM.COMMUN., vol. 4, 1998, pages 455 - 456
KOSHKIN ET AL., TETRAHEDRON, vol. 54, 1998, pages 3607 - 3630
MARTIN ET AL., HELV. CHIM. ACTA, vol. 78, 1995, pages 486 - 504
KABANOV ET AL., FEBS LETT, vol. 259, 1990, pages 327 - 330
ANGEWANDTE CHEMIE, vol. 30, 1991, pages 613
MANOHARAN ET AL., BIOORG. MED. CHEM. LET., vol. 3, 1993, pages 2765 - 2770
LETSINGER ET AL., PROC. NATL. ACID. SCI. USA, vol. 86, 1989, pages 6553 - 6556
MANOHARAN ET AL., BIOORG. MED. CHEM. LET., vol. 4, 1994, pages 1053 - 1060
MANOHARAN ET AL., ANN. N.Y. ACAD. SCI., vol. 660, 1992, pages 306 - 309
OBERHAUSER ET AL., NUCL. ACIDS RES., vol. 20, 1992, pages 533 - 538
SAISON-BEHMOARAS ET AL., EMBO J, vol. 10, 1991, pages 1111 - 1118
SVINARCHUK ET AL., BIOCHIMIE, vol. 75, 1993, pages 49 - 54
MANOHARAN ET AL., TETRAHEDRON LETT, vol. 36, 1995, pages 3651 - 3654
SHEA ET AL., NUCL. ACIDS RES., vol. 18, 1990, pages 3777 - 3783
MANOHARAN ET AL., NUCLEOSIDES & NUCLEOTIDES, vol. 14, 1995, pages 969 - 973
MISHRA ET AL., BIOCHIM. BIOPHYS. ACTA, vol. 1264, 1995, pages 229 - 237
CROOKE ET AL., J. PHARMACOL. EXP. THER., vol. 277, 1996, pages 923 - 937
ZAHLER, A.M.WILLIAMSON, J.R.CECH, T.R.PRESCOTT. D.M.: "Suppression of Telomerase by G-quarter DMA Structures", NATURE, vol. 350, 1991, pages 718 - 720
PARKINSON G NLEE M P HNEIDLE S: "Crystal structure of parallel quadruplexes from human telomeric DNA", NATURE, vol. 417, no. 6891, 2002, pages 876 - 880, XP002979541, DOI: 10.1038/nature755
WANG YPATEL D J: "Solution structure of the human telomeric repeat d[AG3(T2AG3)3] G-tetraplex", STRUCTURE, vol. 1, no. 4, 1993, pages 263 - 282, XP024247899, DOI: 10.1016/0969-2126(93)90015-9
DAI J.CARVER M.YANG D: "Polymorphism of human telonieric quadruples structures", BIOCHIMIE, vol. 90, no. 8, 2008, pages 1172 - 1183
Attorney, Agent or Firm:
BEIJING CHENGHUI LAW FIRM (CN)
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