Title:
METHOD FOR ENRICHING FETAL FREE NUCLEIC ACIDS AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/205132
Kind Code:
A1
Abstract:
A method for enriching fetal free nucleic acids, comprising performing PCR amplification on a sample containing fetal free nucleic acids to obtain a fetal free nucleic acid-enriched product; PCR amplification comprises first performing first linear amplification on the sample by using a forward or reverse primer of a primer pair, and then adding the other primer to a product of first amplification for second exponential amplification so as to obtain the fetal free nucleic acid-enriched product.
Inventors:
YANG LIN (CN)
WANG YICONG (CN)
GAO YA (CN)
CHEN FANG (CN)
ZHANG XIANGHAN (CN)
YU JING (CN)
ZHANG HAIPING (CN)
WANG YICONG (CN)
GAO YA (CN)
CHEN FANG (CN)
ZHANG XIANGHAN (CN)
YU JING (CN)
ZHANG HAIPING (CN)
Application Number:
PCT/CN2018/085080
Publication Date:
October 31, 2019
Filing Date:
April 28, 2018
Export Citation:
Assignee:
BGI SHENZHEN (CN)
International Classes:
C12N15/11; C12Q1/68
Foreign References:
| CN107002080A | 2017-08-01 | |||
| CN1697882A | 2005-11-16 | |||
| CN106795552A | 2017-05-31 |
Attorney, Agent or Firm:
DHC IP ATTORNEYS (CN)
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