METHOD FOR ESTIMATING GLOMERULAR FILTRATION RATE FROM MEASUREMENT VALUE OF MEGALIN IN URINE

Title:

METHOD FOR ESTIMATING GLOMERULAR FILTRATION RATE FROM MEASUREMENT VALUE OF MEGALIN IN URINE

Document Type and Number:

WIPO Patent Application WO/2014/129490

Kind Code:

A1

Abstract:

The present invention addresses the problem of providing a method for simply and non-invasively estimating glomerular renal function. Accordingly, the inventors achieved the present invention upon discovering that: there is a strong correlation between estimated glomerular filtration rate (eGFR) and the excretion amount of megalin in urine of patients with renal disease; and GFR can be non-invasively estimated with high probability by measuring megalin in urine.

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Inventors:

YAMAGATA KUNIHIRO (JP)
HIWATASHI AKIRA (JP)
HAGIWARA MASAHIRO (JP)
KUROSAWA HIROYUKI (JP)
HIRAYAMA YOSHIAKI (JP)

Application Number:

PCT/JP2014/053871

Publication Date:

August 28, 2014

Filing Date:

February 19, 2014

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Assignee:

DENKA SEIKEN KK (JP)

International Classes:

G01N33/68; G01N33/493

Domestic Patent References:

WO2010126055A1	2010-11-04
WO2002037099A1	2002-05-10
WO2010126055A1	2010-11-04
WO2010126043A1	2010-11-04

Foreign References:

JP2010256250A	2010-11-11
JP2013030206A	2013-02-07

Other References:

HIWATASHI, AKIRA ET AL.: "GFR ESTIMATION BY URINARY SOLUBLE MEGALIN", NEPHROLOGY DIALYSIS TRANSPLANTATION, vol. 28, no. SUPPL., May 2013 (2013-05-01), pages 145, XP008181995
CHRISTENSEN E. I.; WILLNOW T. E., J. AM. SOC. NEPHROL., vol. 10, 1999, pages 2224 - 2236
ZHENG G; MCCLUSKEY R. T. ET AL., J. HISTOCHEM. CYTOCHEM., vol. 42, 1994, pages 531 - 542
FLAVIA F. J.; JULIE R. I. ET AL., KIDNEY. INTERNATIONAL., vol. 53, 1998, pages 358 - 366
JAPANESE EQUATION FOR ESTIMATING GFR, March 2008 (2008-03-01)
MARCH 2008, JAPANESE EQUATION FOR ESTIMATING GFR
See also references of EP 2960655A4

Attorney, Agent or Firm:

HIRAKI Yusuke et al. (JP)
Yusuke Hiraki (JP)

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