Title:
METHOD FOR ESTIMATING PATHOLOGICAL TISSUE DIAGNOSIS RESULT (GLEASON SCORE) OF PROSTATE CANCER
Document Type and Number:
WIPO Patent Application WO/2017/056844
Kind Code:
A1
Abstract:
The present invention provides a method for obtaining an index value that is used in a pathological tissue diagnosis of prostate cancer, which can be performed at low invasiveness and at low cost. The method according to the present invention is a method for estimating a Gleason score that represents the degree of malignancy of prostate cancer. In the method, the content of a prostate-specific antigen (PSA), which is an antigen having an N-acetylgalactosamine residue at a non-reductive terminal of a sugar chain, in a sample is determined, and it is estimated that the Gleason score is 7 or more when the measurement value is greater than a threshold value, or it is estimated that the Gleason score is 6 or less when the measurement value is smaller than the threshold value. It is preferred that the quantification of the PSA is carried out by a method involving a step of binding a molecule having affinity for a β-N-acetylgalactosamine residue, e.g., Wisteria floribunda agglutinin (WFA), soybean agglutinin (SBA) or Vicia villosa lectin (VVL), or an anti-β-N-acetylgalactosamine antibody to the PSA.
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Inventors:
KANEKO TOMONORI (JP)
KAYA TAKATOSHI (JP)
KAYA TAKATOSHI (JP)
Application Number:
PCT/JP2016/075771
Publication Date:
April 06, 2017
Filing Date:
September 02, 2016
Export Citation:
Assignee:
KONICA MINOLTA INC (JP)
International Classes:
G01N33/574; C12Q1/02; G01N33/53; G01N33/543
Domestic Patent References:
| WO2010090264A1 | 2010-08-12 |
Foreign References:
| JP2013509565A | 2013-03-14 | |||
| US20090258792A1 | 2009-10-15 |
Other References:
SHINGO HATAKEYAMA: "Zenritsusen Gan no Shindan 6. Byori to GLEASON SCORE", JAPANESE JOURNAL OF CLINICAL UROLOGY, vol. 68, no. 4, 2014, pages 65 - 69, XP009505463
KAZUTOSHI FUJITA: "Fucosylated Haptoglobin wa Zenritsusen Gan kara Sansei sare, Kesseichi wa GLEASON SCORE7 Ijo o Yosoku suru", JAPAN SOCIETY OF ANDROLOGY SOKAI KIJI, vol. 34 th, 17 June 2015 (2015-06-17), pages 149 - 150, XP009505469
MASARU OI: "Zenritsusen Gan no Rinshobyo-ki to PSA-chi.GLEASON SCORE no Kankei", KITAKANTO MED J, vol. 51, no. 2, 2001, pages 176, XP009505459
FEFERMAN L ET AL.: "ARYLSULFATASE B (N- ACETYLGALACTOSAMINE-4-SULFATASE): POTENTIAL ROLE AS A BIOMARKER IN PROSTATE CANCER", PROSTATE CANCER PROSTATIC DIS, vol. 16, no. 3, 2013, pages 277 - 284, XP055372263
SEIICHI SAITO: "RM2 Antigen (.BETA.1,4-GalNAc- Disialyl-Lc4): A Novel Carbohydrate Marker for Prostate Cancer", BIOTHERAPY, vol. 20, no. 4, 2006, pages 418 - 426, XP009505462
JUNKO AMANO: "Zenritsusen Gan Kanja Kesseichu no Zenritsusen Tokui Kogen PSA no Tosa Kozo Kaiseki", THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH NENKAI YOSHISHU, vol. 27 th, 2007, pages 28, XP009505507
KEIKO FUKUSHIMA: "al,2-Fucosylated and beta-NS- acetylgalactosaminylated prostate-specific antigen as an efficient marker of prostatic cancer", JAPAN SOCIETY FOR MOLECULAR TUMOR MARKER RESEARCH PROGRAM·KOEN SHOROKU, vol. 30 th, 2010, pages 113 - 114, XP009505476
TORU YONEYAMA: "PSA Tosa no Gansei Hen'i o Riyo shita Zenritsusen Gan no Shinki Screening-ho", THE JAPANESE JOURNAL OF UROLOGY, vol. 104, no. 2, 2013, pages 208, XP009505464
TOMONORI KANEKO: "Development of a Prostate Cancer Diagnostic System Based on Surface Plasmon Field-Enhanced Fluorescence Spectroscopy", KONICA MINOLTA TECHNOL REP, vol. 13, January 2016 (2016-01-01), pages 73 - 78, XP009505466
TOBISAWA YUKI: "SERUM LACDINAC-PSA DETERMINED BY SURFACE PLASMON FIELD-ENHANCED FLUORESCENCE SPECTROSCOPY (SPFS)-BASED ASSAY SYSTEM HAS IMPROVED DIAGNOSTIC ACCURACY THAN PSA", JOURNAL OF UROLOGY, vol. 195, no. 4S, April 2016 (2016-04-01), pages E15 - E16, XP029478973
KAZUTOSHI FUJITA: "Fucosylated Haptoglobin wa Zenritsusen Gan kara Sansei sare, Kesseichi wa GLEASON SCORE7 Ijo o Yosoku suru", JAPAN SOCIETY OF ANDROLOGY SOKAI KIJI, vol. 34 th, 17 June 2015 (2015-06-17), pages 149 - 150, XP009505469
MASARU OI: "Zenritsusen Gan no Rinshobyo-ki to PSA-chi.GLEASON SCORE no Kankei", KITAKANTO MED J, vol. 51, no. 2, 2001, pages 176, XP009505459
FEFERMAN L ET AL.: "ARYLSULFATASE B (N- ACETYLGALACTOSAMINE-4-SULFATASE): POTENTIAL ROLE AS A BIOMARKER IN PROSTATE CANCER", PROSTATE CANCER PROSTATIC DIS, vol. 16, no. 3, 2013, pages 277 - 284, XP055372263
SEIICHI SAITO: "RM2 Antigen (.BETA.1,4-GalNAc- Disialyl-Lc4): A Novel Carbohydrate Marker for Prostate Cancer", BIOTHERAPY, vol. 20, no. 4, 2006, pages 418 - 426, XP009505462
JUNKO AMANO: "Zenritsusen Gan Kanja Kesseichu no Zenritsusen Tokui Kogen PSA no Tosa Kozo Kaiseki", THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH NENKAI YOSHISHU, vol. 27 th, 2007, pages 28, XP009505507
KEIKO FUKUSHIMA: "al,2-Fucosylated and beta-NS- acetylgalactosaminylated prostate-specific antigen as an efficient marker of prostatic cancer", JAPAN SOCIETY FOR MOLECULAR TUMOR MARKER RESEARCH PROGRAM·KOEN SHOROKU, vol. 30 th, 2010, pages 113 - 114, XP009505476
TORU YONEYAMA: "PSA Tosa no Gansei Hen'i o Riyo shita Zenritsusen Gan no Shinki Screening-ho", THE JAPANESE JOURNAL OF UROLOGY, vol. 104, no. 2, 2013, pages 208, XP009505464
TOMONORI KANEKO: "Development of a Prostate Cancer Diagnostic System Based on Surface Plasmon Field-Enhanced Fluorescence Spectroscopy", KONICA MINOLTA TECHNOL REP, vol. 13, January 2016 (2016-01-01), pages 73 - 78, XP009505466
TOBISAWA YUKI: "SERUM LACDINAC-PSA DETERMINED BY SURFACE PLASMON FIELD-ENHANCED FLUORESCENCE SPECTROSCOPY (SPFS)-BASED ASSAY SYSTEM HAS IMPROVED DIAGNOSTIC ACCURACY THAN PSA", JOURNAL OF UROLOGY, vol. 195, no. 4S, April 2016 (2016-04-01), pages E15 - E16, XP029478973
Attorney, Agent or Firm:
SSINPAT PATENT FIRM (JP)
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