Title:
METHOD FOR EVALUATING CULTURED CELLS
Document Type and Number:
WIPO Patent Application WO/2010/084943
Kind Code:
A1
Abstract:
Disclosed is a method for evaluating the type or function of cultured cells, such as a method for evaluating a bone formation ability, which has been difficult to achieve based on a certain criterion because of the fluctuations among individuals. In the method for evaluating cultured cells, for the purpose of identifying a cell of interest among the cultured cells, multiple test values or indicators for the cultured cells are measured, and the function of the cell of interest is predicted or determined with high accuracy based on a combination of the multiple test values or indicators.
The method is characterized in that a cell of interest can be identified not only by designating a certain adaptation range for each of the test values, but also referring other test value or indicator for a sample that goes out of the application range.
Inventors:
KAGAMI HIDEAKI (JP)
AGATA HIDEKI (JP)
HORI YUSUKE (JP)
OHSHIMA SATOSHI (JP)
AGATA HIDEKI (JP)
HORI YUSUKE (JP)
OHSHIMA SATOSHI (JP)
Application Number:
PCT/JP2010/050765
Publication Date:
July 29, 2010
Filing Date:
January 22, 2010
Export Citation:
Assignee:
UNIV TOKYO (JP)
TES HOLDINGS CO LTD (JP)
KAGAMI HIDEAKI (JP)
AGATA HIDEKI (JP)
HORI YUSUKE (JP)
OHSHIMA SATOSHI (JP)
TES HOLDINGS CO LTD (JP)
KAGAMI HIDEAKI (JP)
AGATA HIDEKI (JP)
HORI YUSUKE (JP)
OHSHIMA SATOSHI (JP)
International Classes:
C12Q1/04; C12Q1/02; C12Q1/42; G01N33/53; G01N33/543
Foreign References:
| JP2005058225A | 2005-03-10 | |||
| JP2007528706A | 2007-10-18 |
Other References:
KONDO Y ET AL.: "Role of stromal cells in osteoclast differentiation in bone marrow.", J BONE MINER METAB., vol. 19, no. 6, 2001, pages 352 - 358
GUO L ET AL.: "Osteogenic differentiation of human mesenchymal stem cells on chargeable polymer-modified surfaces.", J BIOMED MATER RES A., vol. 87, no. 4, 2008, pages 903 - 912
SYED-PICARD FN ET AL.: "Three-dimensional engineered bone from bone marrow stromal cells and their autogenous extracellular matrix.", TISSUE ENG PART A., vol. 15, no. 1, January 2009 (2009-01-01), pages 187 - 195
ITO A ET AL.: "A new methodology of mesenchymal stem cell expansion using magnetic nanoparticles", BIOCHEMICAL ENGINEERING JOURNAL, vol. 20, no. 2-3, 2004, pages 119 - 125
GUO L ET AL.: "Osteogenic differentiation of human mesenchymal stem cells on chargeable polymer-modified surfaces.", J BIOMED MATER RES A., vol. 87, no. 4, 2008, pages 903 - 912
SYED-PICARD FN ET AL.: "Three-dimensional engineered bone from bone marrow stromal cells and their autogenous extracellular matrix.", TISSUE ENG PART A., vol. 15, no. 1, January 2009 (2009-01-01), pages 187 - 195
ITO A ET AL.: "A new methodology of mesenchymal stem cell expansion using magnetic nanoparticles", BIOCHEMICAL ENGINEERING JOURNAL, vol. 20, no. 2-3, 2004, pages 119 - 125
Attorney, Agent or Firm:
IWAHASHI YUJI (JP)
Yuji Iwahashi (JP)
Yuji Iwahashi (JP)
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