Title:
METHOD FOR EVALUATING FUTURE ONSET RISK OF ALZHEIMER'S TYPE DEMENTIA
Document Type and Number:
WIPO Patent Application WO/2018/008763
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing an evaluation method or the like which is capable of providing highly reliable information which helps one to know the future onset risk of Alzheimer's disease. An embodiment of the present invention evaluates the future onset risk of Alzheimer's disease in a subject to be evaluated, by using one or more of the following concentrations in the blood of a subject to be evaluated who has mild cognitive impairment: α-ABA, Ala, Arg, Asn, Cit, Gln, Glu, Gly, His, Ile, Leu, Lys, Met, Orn, Phe, Pro, Ser, Thr, Trp, Tyr, Val, Cysteine, Taurine, bABA, Ethylglycine, Hypotaurine, 3-Me-His, 5-HydroxyTrp, aAiBA, and N8-Acetylspermidine.
Inventors:
IKEUCHI TAKESHI (JP)
YANO YUKI (JP)
ARASHIDA NAOKO (JP)
NISHIMOTO RUMI (JP)
SHIMBO KAZUTAKA (JP)
KAWAI NOBUHIRO (JP)
YANO YUKI (JP)
ARASHIDA NAOKO (JP)
NISHIMOTO RUMI (JP)
SHIMBO KAZUTAKA (JP)
KAWAI NOBUHIRO (JP)
Application Number:
PCT/JP2017/025050
Publication Date:
January 11, 2018
Filing Date:
July 07, 2017
Export Citation:
Assignee:
AJINOMOTO KK (JP)
International Classes:
G01N33/68
Foreign References:
| JP2014521928A | 2014-08-28 |
Other References:
ORESIC, M. ET AL.: "Metabolome in progression to Alzheimer's disease", TRANSLATIONAL PSYCHIATRY, vol. 1, no. e57, 13 December 2011 (2011-12-13), pages 1 - 9, XP009162723
HYE, A. ET AL.: "Plasma proteins predict conversion to dementia from prodromal disease", ALZHEIMER'S & DEMENTIA, vol. 10, no. 6, 2014, pages 799 - 807, XP055174569
GRAHAM, S.F. ET AL.: "Untargeted Metabolomic Analysis of Human plasma Indicates Differentially Affected Polyamine and L-Arginine Metabolism in Mild Cognitive Impairment Subjects Converting to Alzheimer's Disease", PLOS ONE, 2015, pages 1 - 16, XP055384921
HYE, A. ET AL.: "Plasma proteins predict conversion to dementia from prodromal disease", ALZHEIMER'S & DEMENTIA, vol. 10, no. 6, 2014, pages 799 - 807, XP055174569
GRAHAM, S.F. ET AL.: "Untargeted Metabolomic Analysis of Human plasma Indicates Differentially Affected Polyamine and L-Arginine Metabolism in Mild Cognitive Impairment Subjects Converting to Alzheimer's Disease", PLOS ONE, 2015, pages 1 - 16, XP055384921
Attorney, Agent or Firm:
SAKAI INTERNATIONAL PATENT OFFICE (JP)
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