Title:
METHOD FOR EVALUATING PROGRESSION LEVEL OF DIABETIC DISEASE
Document Type and Number:
WIPO Patent Application WO/2012/121266
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a urinary test method whereby the early symptoms of a disease caused by diabetes can be diagnosed and the controlled state after intervention can be appropriately evaluated. More specifically, the purpose of the present invention is to provide a method for evaluating urinary test data whereby the early symptoms of diabetic nephropathy can be appropriately diagnosed.
For this purpose, the present inventors examined diabetes-related antigens (biomarkers) discharged in urine by using the immune-complex transfer enzyme immunoassay (ICT-EIA) method. As a result, it was clarified that the progress of renal dysfunction, together with the progress of diabetes, can be understood at early stage by the combined use of multiple kinds of biomarkers. The present invention was thus completed.
Inventors:
HASHIDA SEIICHI (JP)
UMEHARA ASAKO (JP)
UMEHARA ASAKO (JP)
Application Number:
PCT/JP2012/055736
Publication Date:
September 13, 2012
Filing Date:
February 29, 2012
Export Citation:
Assignee:
HASHIDA SEIICHI (JP)
UMEHARA ASAKO (JP)
UMEHARA ASAKO (JP)
International Classes:
G01N33/543; A61B10/00; G01N33/53
Foreign References:
| JP2009085685A | 2009-04-23 | |||
| JP2001116751A | 2001-04-27 |
Other References:
MAMIKO NISHIOKA ET AL.: "Development of the Diabetic Risk Evaluation using Resistin and Insulin Receptor-alpha in Urine and the Application to Exercise/Nutrition Education", TECHNICAL BULLETIN OF TOKUSHIMA BUNRI UNIVERSITY, no. 76, 2008, pages 1 - 19
YUSUKE MIYAZAWA ET AL.: "Development of a highly sensitive enzyme immunoassay for insulin and application to evaluation of the diabetic risk by urine in the morning", TECHNICAL BULLETIN OF TOKUSHIMA BUNRI UNIVERSITY, vol. 77, 2009, pages 19 - 28
TAKUMA NARITA ET AL.: "A new method ot detect the clinical sign of intraglomerular hypertension in human and its significance in analyis of mechanisms of development and progression of early stage of diabetic nephropathy", AKITA IGAKU, vol. 32, no. 2, 2005, pages 89 - 93
NAOKI KANEMATSU ET AL.: "Development of a novel highly sensitive immunoassay for adiponectin using dried blood on filter paper disc and application to assess changes in adiponectin due to exercise / tea-catechin intake", TECHNICAL BULLETIN OF TOKUSHIMA BUNRI UNIVERSITY, vol. 78, 2009, pages 7 - 23
MAMIKO NISHIOKA ET AL.: "Nyochu Resistin Oyobi Nyochu Insulin Juyotai a ni yoru Tonyobyo Risk Shihyo no Kochiku to Eiyo Management eno Oyo", EIYOGAKU ZASSHI, vol. 65, no. 5, 2007, pages 158
MAMIKO NISHIOKA ET AL.: "Nyochu Resistin Oyobi Yuri Insulin Juyotai a ni yoru Tonyobyo Risk Shihyo no Kochiku to Eiyo Assessment eno Oyo", THE JAPANESE SOCIETY OF NUTRITION AND FOOD SCIENCE TAIKAI KOEN YOSHISHU, vol. 62, 2008, pages 285
GLASSOCK RICHARD J.: "Diabetic Nephropathy: Staging and Progression", DIABETES FRONT, vol. 21, no. 6, 2010, pages 728
YUSUKE MIYAZAWA ET AL.: "Development of a highly sensitive enzyme immunoassay for insulin and application to evaluation of the diabetic risk by urine in the morning", TECHNICAL BULLETIN OF TOKUSHIMA BUNRI UNIVERSITY, vol. 77, 2009, pages 19 - 28
TAKUMA NARITA ET AL.: "A new method ot detect the clinical sign of intraglomerular hypertension in human and its significance in analyis of mechanisms of development and progression of early stage of diabetic nephropathy", AKITA IGAKU, vol. 32, no. 2, 2005, pages 89 - 93
NAOKI KANEMATSU ET AL.: "Development of a novel highly sensitive immunoassay for adiponectin using dried blood on filter paper disc and application to assess changes in adiponectin due to exercise / tea-catechin intake", TECHNICAL BULLETIN OF TOKUSHIMA BUNRI UNIVERSITY, vol. 78, 2009, pages 7 - 23
MAMIKO NISHIOKA ET AL.: "Nyochu Resistin Oyobi Nyochu Insulin Juyotai a ni yoru Tonyobyo Risk Shihyo no Kochiku to Eiyo Management eno Oyo", EIYOGAKU ZASSHI, vol. 65, no. 5, 2007, pages 158
MAMIKO NISHIOKA ET AL.: "Nyochu Resistin Oyobi Yuri Insulin Juyotai a ni yoru Tonyobyo Risk Shihyo no Kochiku to Eiyo Assessment eno Oyo", THE JAPANESE SOCIETY OF NUTRITION AND FOOD SCIENCE TAIKAI KOEN YOSHISHU, vol. 62, 2008, pages 285
GLASSOCK RICHARD J.: "Diabetic Nephropathy: Staging and Progression", DIABETES FRONT, vol. 21, no. 6, 2010, pages 728
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