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Title:
METHOD FOR EVALUATING RISK OF TYPE 2 DIABETES USING BLOOD METABOLITES AS AN INDEX
Document Type and Number:
WIPO Patent Application WO/2020/105562
Kind Code:
A1
Abstract:
It is an object of the present invention to provide a novel method capable of evaluating risk of Type 2 diabetes. The present invention is related to a method for evaluating risk of Type 2 diabetes using blood metabolites as an index, wherein the blood metabolite comprises at least one metabolite selected from the group consisting of NADP+, (iso)Valeryl-carnitine, 2-Hydroxybutyrate, 3-Hydroxybutyrate, Acetyl-carnitine, Proline, ADP, Urate, Sedoheptulose-7-phosphate, N-Acetyl-aspartate, Glycerophosphoethanolamine, 6-Phosphogluconate, Quinolinic acid, N-Acetyl-glucosamine, UMP, Adenine, Succinate, Cytidine, Phosphoenolpyruvate, Fructose-6-phosphate, Keto(iso)leucine, Glyceraldehyde-3-phosphate, Pentose-phosphate, UDP-glucuronate, N-Methyl-adenosine, UTP, Citrulline, S-Adenosyl-methionine, Dimethyl-arginine, Indoxyl-sulfate, Kynurenine, UDP-glucose, Dimethyl-guanosine, N2-Acetyl-arginine, Glutathione disulfide, Phenylalanine, AMP, Serine, Threonine, 1,5-Anhydroglucitol, Taurine, Trimethyl-lysine, and Pseudouridine.

Inventors:
YANAGIDA MITSUHIRO (JP)
TERUYA TAKAYUKI (JP)
Application Number:
JP2019/044926
Publication Date:
May 28, 2020
Filing Date:
November 15, 2019
Export Citation:
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Assignee:
OKINAWA INST SCIENCE & TECH SCHOOL CORP (JP)
International Classes:
G01N33/50
Domestic Patent References:
WO2006022633A12006-03-02
WO2003078618A12003-09-25
WO2003023063A12003-03-20
WO2013151053A12013-10-10
Foreign References:
US5800998A1998-09-01
JP2004141013A2004-05-20
Other References:
KUNJARA, S: "Pyrimidine nucleotide synthesis in the rat kidney in early diabetes", BIOCHEMIC; MEDICINE AND METABOLIC BIOLOGY, vol. 46, no. 2, 1991, pages 215 - 225, XP026189992, DOI: 10.1016/0885-4505(91)90069-W
Attorney, Agent or Firm:
TSUKUNI & ASSOCIATES (JP)
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