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Title:
METHOD FOR EVALUATING SEVERITY OF DENGUE VIRUS INFECTION IN INDIVIDUAL, DETECTION DEVICE AND DETECTION KIT
Document Type and Number:
WIPO Patent Application WO/2018/223380
Kind Code:
A1
Abstract:
Provided is a method for evaluating the severity of the dengue virus infection in an individual, executed by means of detecting a biological sample of an individual in vitro. The method comprises: detecting whether a non-structural protein 1 is present in a biological sample in vitro to obtain a first detection result; detecting whether a complex is present in the biological sample in vitro to obtain a second detection result, wherein the complex comprises the non-structural protein 1 and a thrombin, or comprises the non-structural protein 1 and a prothrombin; and evaluating the severity of the dengue virus infection in the individual via the first detection result and the second detection result. Also provided are a detection device and a detection kit for evaluating the severity of the dengue virus infection in an individual.

Inventors:
HO TZONG-SHIANN (CN)
CHUANG YUNG-CHUN (CN)
HSU PO-CHIH (CN)
CHENG YU-WEI (CN)
LIU CHING-CHUANG (CN)
YEH TRAI-MING (CN)
Application Number:
PCT/CN2017/087750
Publication Date:
December 13, 2018
Filing Date:
June 09, 2017
Export Citation:
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Assignee:
HO TZONG SHIANN (CN)
International Classes:
C12Q1/68; G01N33/569
Foreign References:
TW201321753A2013-06-01
US20160363590A12016-12-15
CN101576560A2009-11-11
Other References:
LIN, S.W. ET AL.: "Dengue Virus Nonstructural Protein NS1 Binds to Prothrombin/Thrombin and Inhibits Prothrombin Activation", JOURNAL OF INFECTION., vol. 64, no. 3, March 2012 (2012-03-01), pages 325 - 334, XP055554576
CHEN, YUE ET AL.: "A (Research Progress in the Structure and Function of Dengue Virus Non-structural 1 Protein", CHINESE JOURNAL OF VIROLOGY, vol. 30, no. 6, 30 November 2014 (2014-11-30), pages 683 - 688
MEI, ZHU ET AL.: "Progress in Research on NS1 Protein of Dengue Viruses", BULLETIN OF THE ACADEMY OF MILITARY MEDICAL SCIENCES, vol. 34, no. 3, 30 June 2010 (2010-06-30), pages 286 - 289
Attorney, Agent or Firm:
JEEKAI & PARTNERS (CN)
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