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Title:
METHOD OF EXAMINING STEROID-RESPONSIVENESS
Document Type and Number:
WIPO Patent Application WO/2002/071064
Kind Code:
A1
Abstract:
A gene CYP1B1 showing a large difference in expression level in monocytes between a steroid-responsive group and a weakly steroid-responsive group of patients with atopic dermatitis. CYP1B1 is a gene showing a decrease in the expression level in monocytes of the weakly steroid-responsive group. A method of examining steroid-responsiveness and a method of screening a compound useful in improving steroid-responsiveness with the use of the expression levels of such a gene in biological samples as indication are provided.

Inventors:
Sugita, Yuji c/o Genox Research (Inc. Teikyo University Biotech Center, 907, Nogawa, Miyamae-k, Kawasaki-shi Kanagawa, 216-0001, JP)
Heishi, Masayuki c/o Genox Research (Inc. Teikyo University Biotech Center, 907, Nogawa, Miyamae-k, Kawasaki-shi Kanagawa, 216-0001, JP)
Kagaya, Shinji c/o Genox Research (Inc. Teikyo University Biotech Center, 907, Nogawa, Miyamae-k, Kawasaki-shi Kanagawa, 216-0001, JP)
Gunji, Shigemichi c/o Clinical, Quality Assurance Unit (New Drug Development Division Sankyo Co., Ltd., 2-7-12, Ginz, Chuo-ku Tokyo, 104-8113, JP)
Saito, Hirohisa c/o Research Institute (National Center for Child Health and Development 3-35-31, Taishid, Setagaya-ku Tokyo, 154-8509, JP)
Application Number:
PCT/JP2002/001915
Publication Date:
September 12, 2002
Filing Date:
March 01, 2002
Export Citation:
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Assignee:
GENOX RESEARCH, INC. (5-1-3, Tokodai Tsukuba-shi, Ibaraki, 300-2635, JP)
JAPAN as represented by GENERAL DIRECTOR OF AGENCY OF NATIONAL CENTER FOR CHILD HEALTH AND DEVELOPMENT (10-1, Okura 2-chome Setagaya-ku, Tokyo, 157-8535, JP)
Sugita, Yuji c/o Genox Research (Inc. Teikyo University Biotech Center, 907, Nogawa, Miyamae-k, Kawasaki-shi Kanagawa, 216-0001, JP)
Heishi, Masayuki c/o Genox Research (Inc. Teikyo University Biotech Center, 907, Nogawa, Miyamae-k, Kawasaki-shi Kanagawa, 216-0001, JP)
Kagaya, Shinji c/o Genox Research (Inc. Teikyo University Biotech Center, 907, Nogawa, Miyamae-k, Kawasaki-shi Kanagawa, 216-0001, JP)
Gunji, Shigemichi c/o Clinical, Quality Assurance Unit (New Drug Development Division Sankyo Co., Ltd., 2-7-12, Ginz, Chuo-ku Tokyo, 104-8113, JP)
Saito, Hirohisa c/o Research Institute (National Center for Child Health and Development 3-35-31, Taishid, Setagaya-ku Tokyo, 154-8509, JP)
International Classes:
A01K67/027; A61K31/711; A61K38/00; A61K45/00; A61P37/08; A61P43/00; C12N9/02; C12N15/09; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; (IPC1-7): G01N33/53; A01K67/027; G01N33/68
Other References:
BRAKE P.B. ET AL.: 'Regulation of expression of CYP1BI by steroid-hormones and the AH receptor in the rat mammary gland' FASEB JOURNAL ABSTRACTS vol. 11, no. 9, 1997, page A3054, XP002955849
IMAD H. HANNA ET AL.: 'Cytochrome P4501b1(CYP1B1) pharmacogenics: Association of polymorphisms with functial differences in estrogen hydroxylation activity' CANCER RESEARCH vol. 60, 2000, pages 3440 - 3444, XP002196668
SHIMADA CHIKARA: 'Hito no P450 idenshi no tagata to kagaku busshitsu no seitai eikyo' THE JAPANESE JOURNAL OF TOXICOLOGY vol. 12, 1999, pages 377 - 382, XP002955850
Attorney, Agent or Firm:
Shimizu, Hatsushi (Kantetsu Tsukuba Bldg. 6F, 1-1-1 Oroshi-mach, Tsuchiura-shi Ibaraki, 300-0847, JP)
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