Title:
A METHOD FOR EXTENDING HALF-LIFE OF A PROTEIN
Document Type and Number:
WIPO Patent Application WO/2017/086627
Kind Code:
A1
Abstract:
The present invention relates to a method for prolonging half-life of a protein or a (poly)peptide by replacing one or more amino acid residues of the protein. Further, the present invention is about the protein having a prolonged half-life prepared by the method above.
Inventors:
KIM KYUNGGON (KR)
BAEK KWANG-HYUN (KR)
BAE SUNG-RYUL (KR)
KIM MYUNG-SUN (KR)
KIM HYEONMI (KR)
YOO YEEUN (KR)
LI LAN (CN)
PARK JUNG-HYUN (KR)
KIM JIN-OK (KR)
BAEK KWANG-HYUN (KR)
BAE SUNG-RYUL (KR)
KIM MYUNG-SUN (KR)
KIM HYEONMI (KR)
YOO YEEUN (KR)
LI LAN (CN)
PARK JUNG-HYUN (KR)
KIM JIN-OK (KR)
Application Number:
PCT/KR2016/012334
Publication Date:
May 26, 2017
Filing Date:
October 30, 2016
Export Citation:
Assignee:
UBIPROTEIN CORP (KR)
International Classes:
C07K14/47; A61K38/17; A61K38/18; A61K38/19; A61K38/22; C07K14/505; C07K14/535; C07K14/56; C07K14/61; C07K14/62
Domestic Patent References:
| WO2009155464A2 | 2009-12-23 |
Foreign References:
| US20070048837A1 | 2007-03-01 |
Other References:
BATONNET ET AL.: "Critical Role for Lysine 133 in the Nuclear Ubiquitin-mediated Degradation of MyoD", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, 13 February 2004 (2004-02-13), pages 5413 - 5420, XP055383641
SOKALINGAM ET AL.: "A Study on the Effect of Surface Lysine to Arginine Mutagenesis on Protein Stability and Structure Using Green Fluorescent Protein", PLOS ONE, vol. 7, no. 7, 9 July 2012 (2012-07-09), pages 1 - 12, XP055215564
LEITES ET AL.: "Altering protein degradation via the ubiquitin proteasomal system or autophagy, and its impact on tau degradation and aggregation", PHD THESIS UNIVERSIDADE DE COIMBRA, 2014, pages 1 - 108, XP055383649
CELL, vol. 153, no. 4, 2013, pages 747758 - 758
CELL METAB., vol. 18, no. 1, 2013, pages 5 - 6
FRONT ENDOCRINOL (LAUSANNE, vol. 4, 2013, pages 146
J BIOL CHEM., vol. 279, no. 4, 2004, pages 2368 - 2376
CELL RESEARCH, vol. 22, 2012, pages 873885
ONCOGENE, vol. 22, 2003, pages 12731280
CELL, vol. 78, 1994, pages 787 - 798
SOKALINGAM ET AL.: "A Study on the Effect of Surface Lysine to Arginine Mutagenesis on Protein Stability and Structure Using Green Fluorescent Protein", PLOS ONE, vol. 7, no. 7, 9 July 2012 (2012-07-09), pages 1 - 12, XP055215564
LEITES ET AL.: "Altering protein degradation via the ubiquitin proteasomal system or autophagy, and its impact on tau degradation and aggregation", PHD THESIS UNIVERSIDADE DE COIMBRA, 2014, pages 1 - 108, XP055383649
CELL, vol. 153, no. 4, 2013, pages 747758 - 758
CELL METAB., vol. 18, no. 1, 2013, pages 5 - 6
FRONT ENDOCRINOL (LAUSANNE, vol. 4, 2013, pages 146
J BIOL CHEM., vol. 279, no. 4, 2004, pages 2368 - 2376
CELL RESEARCH, vol. 22, 2012, pages 873885
ONCOGENE, vol. 22, 2003, pages 12731280
CELL, vol. 78, 1994, pages 787 - 798
Attorney, Agent or Firm:
LEE, Jong Seung (KR)
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