Title:
METHOD FOR EXTRACTING ALCOHOL-SOLUBLE SUBSTANCE FROM BARK OF PINUS SYLVESTRIS
Document Type and Number:
WIPO Patent Application WO/2016/101335
Kind Code:
A1
Abstract:
A method for extracting an alcohol-soluble substance from bark of pinus sylvestris, the method comprising the following steps: (1) pulverizing bark of pinus sylvestris into particles having a size of 20-80 mesh, adding the same into n-hexane/chloroform, and performing sonication to obtain a mixture A; (2) filtering the mixture A to obtain a filtrate a and filter residues; distilling the filtrate a to evaporate the n-hexane/chloroform so as to obtain a lipid substance; (3) adding the filter residue to an ethanol solution and sonicating the same; and (4) filtering the mixture B to obtain a filtrate b, distilling the filtrate b to evaporate the ethanol solution so as to obtain a concentrated alcohol-soluble substance in liquid form, and drying the concentrated liquid to obtain the alcohol-soluble substance. The alcohol-soluble substance extracted using the method has a high flavone content, comprises effective ingredients such as sinapic acid, secoisolariciresinol and 9'-p-hydroxy (trans) cinnamate-7-hydroxy-secoisolariciresinol, and has anti-oxidant and anti-bacterial effects.
Inventors:
SUN HAODONG (CN)
SUN DAQING (CN)
WANG GUIHUA (CN)
SUN DAQING (CN)
WANG GUIHUA (CN)
Application Number:
PCT/CN2015/000921
Publication Date:
June 30, 2016
Filing Date:
December 22, 2015
Export Citation:
Assignee:
SUN HAODONG (CN)
SUN DAQING (CN)
WANG GUIHUA (CN)
SUN DAQING (CN)
WANG GUIHUA (CN)
International Classes:
C07D311/40; A61K36/15; C07C41/34; C07C43/23; C07C51/42; C07C59/64; C07C67/48; C07C69/732; C07D311/30; C07D311/32
Foreign References:
| CN104557836A | 2015-04-29 |
Other References:
MAARIT KARONEN ET AL.: "Phenolic Extractives from the Bark of Pinus Sylvestris L. and Their Effects on Inflammatory Mediators Nitric Oxide and Prostaglandin E2", J, AGRIC. FOOD CHEM., vol. 52, no. 25, 10 November 2004 (2004-11-10), pages 7532 - 7540
GU, JIAN ET AL.: "Effective Components of the Pine Bark", HEILONGJIANG MEDICINE AND PHARMACY, vol. 32, no. 3, 30 June 2009 (2009-06-30), pages 4
GU, JIAN ET AL.: "Effective Components of the Pine Bark", HEILONGJIANG MEDICINE AND PHARMACY, vol. 32, no. 3, 30 June 2009 (2009-06-30), pages 4
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