Title:
METHOD FOR EXTRACTING CHLOROGENIC ACID FROM CHINESE WOLFBERRY
Document Type and Number:
WIPO Patent Application WO/2017/185274
Kind Code:
A1
Abstract:
A method for extracting chlorogenic acid from Chinese wolfberry, comprising the following steps: drying, grinding, sifting, and degreasing Chinese wolfberry, to obtain a filter cake; drying the filter cake, adding the filter cake to acetone for ultrasonic extraction, and performing filtering to obtain an extract solution and residue; performing supercritical carbon dioxide extraction on the residue to obtain an extract liquor; after mixing the extract liquor and the extract solution, treating the mixture with a macroporous absorption resin, and then performing eluting by using water and acetone in sequence, concentrating, and drying, to obtain chlorogenic acid. The conditions of supercritical extraction comprises that: the extraction temperature is 65-70°C, the temperature of the first separation is 55-60°C, the temperature of the second separation is 45-50°C, the extraction pressure is 40-50 MPa, the flow rate of carbon dioxide is 30-60 L/h, the frequency of receiving a product is 45-50 min per time, and the extraction time is 2-3 h. The method not only improves the extraction speed and extraction precision, but also reduces the production costs.
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Inventors:
ZHU XIAOTAO (CN)
Application Number:
PCT/CN2016/080454
Publication Date:
November 02, 2017
Filing Date:
April 28, 2016
Export Citation:
Assignee:
ZHU XIAOTAO (CN)
International Classes:
C07C69/732; C07C67/56
Foreign References:
| CN104326913A | 2015-02-04 | |||
| CN101817749A | 2010-09-01 | |||
| CN104256604A | 2015-01-07 | |||
| CN104257882A | 2015-01-07 | |||
| JPH09266767A | 1997-10-14 |
Other References:
SHAN, YONGKAI: "Extra Technology of chlorogenic acid from lycium", FOOD AND MACHINERY, vol. 28, no. 5, 30 September 2012 (2012-09-30), pages 127 - 130
HUANG, SHAOCHONG.: "Application and Extraction of Chlorogenic Acid", APPLIED CHEMICAL INDUSTRY, vol. 35, no. 6, 30 June 2006 (2006-06-30), pages 467 - 469
LIU, JUNHAI ET AL.: "Progress Report on the Methods of Extraction and Purifucation, Separationand Purification, Separation of Chlorogenic Acid", CEREALS AND OILS, 31 December 2007 (2007-12-31), pages 42 - 45
HUANG, SHAOCHONG.: "Application and Extraction of Chlorogenic Acid", APPLIED CHEMICAL INDUSTRY, vol. 35, no. 6, 30 June 2006 (2006-06-30), pages 467 - 469
LIU, JUNHAI ET AL.: "Progress Report on the Methods of Extraction and Purifucation, Separationand Purification, Separation of Chlorogenic Acid", CEREALS AND OILS, 31 December 2007 (2007-12-31), pages 42 - 45
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