Title:
METHOD FOR THE FERMENTATIVE PRODUCTION OF L-VALINE USING A CORYNEBACTERIUM GLUTAMICUM HAVING INCREASED TRANSAMINASE C ACTIVITY
Document Type and Number:
WIPO Patent Application WO2006034667
Kind Code:
A3
Abstract:
The invention relates to a method for producing L-valine and to a suitable microorganism. The inventive method is characterized by preferably enhancing the transaminase C activity of a coryneform bacterium, especially Corynebacterium glutamicum. The organisms so modified have a yield in L-valine which is 35.8 % higher than that of non-modified organisms.
Inventors:
MARIENHAGEN JAN (DE)
EGGELING LOTHAR (DE)
SAHM HERMANN (DE)
EGGELING LOTHAR (DE)
SAHM HERMANN (DE)
Application Number:
PCT/DE2005/001465
Publication Date:
July 20, 2006
Filing Date:
August 19, 2005
Export Citation:
Assignee:
FORSCHUNGSZENTRUM JUELICH GMBH (DE)
MARIENHAGEN JAN (DE)
EGGELING LOTHAR (DE)
SAHM HERMANN (DE)
MARIENHAGEN JAN (DE)
EGGELING LOTHAR (DE)
SAHM HERMANN (DE)
International Classes:
C12N1/21; C12P13/08
Foreign References:
| EP1155139B1 | 2003-04-09 | |||
| EP1275729A1 | 2003-01-15 |
Other References:
WANG, M.D. ET AL.: "Cloning of Genes That Suppress an Escherichia coli K-12 Alanine Auxotroph When Present in Multicopy Plasmids", JOURNAL OF BACTERIOLOGY, vol. 169, no. 12, December 1987 (1987-12-01), pages 5610 - 5614, XP002380800
LEYVAL, D. ET AL.: "Characterisation of the enzyme activities involved in the valine biosynthetic pathway in a valine-producing strain of Corynebacterium glutamicum", JOURNAL OF BIOTECHNOLOGY, vol. 104, no. 1-3, 2003, pages 241 - 252, XP002380799
DATABASE NCBI [online] 5 August 2004 (2004-08-05), NAKAGAWA, S.: "Complete genomic sequence of Corynebacterium glutamicum ATCC 13032", XP002380803, Database accession no. NC_003450
MARIENHAGEN, J. ET AL.: "Functional Analysis of All Aminotransferase Proteins Inferred from the Genome Sequence of Corynebacterium glutamicum", JOURNAL OF BACTERIOLOGY, vol. 187, no. 22, November 2005 (2005-11-01), pages 7639 - 7646, XP002380801
LEYVAL, D. ET AL.: "Characterisation of the enzyme activities involved in the valine biosynthetic pathway in a valine-producing strain of Corynebacterium glutamicum", JOURNAL OF BIOTECHNOLOGY, vol. 104, no. 1-3, 2003, pages 241 - 252, XP002380799
DATABASE NCBI [online] 5 August 2004 (2004-08-05), NAKAGAWA, S.: "Complete genomic sequence of Corynebacterium glutamicum ATCC 13032", XP002380803, Database accession no. NC_003450
MARIENHAGEN, J. ET AL.: "Functional Analysis of All Aminotransferase Proteins Inferred from the Genome Sequence of Corynebacterium glutamicum", JOURNAL OF BACTERIOLOGY, vol. 187, no. 22, November 2005 (2005-11-01), pages 7639 - 7646, XP002380801
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