Title:
METHOD FOR FILTRATION OF CELL-DERIVED VESICLE
Document Type and Number:
WIPO Patent Application WO/2021/221368
Kind Code:
A1
Abstract:
The present invention relates to a method for isolating cell-derived vesicles at high purity and selectively filtering cell-derived vesicles from a suspension containing cell-derived vesicles and, more specifically, to a method for isolation and selective filtration of cell-derived vesicles from a suspension containing cell-derived vesicles through efficient discrimination against impurities cell debris, waste products, proteins, and macro-particles. Using the method for isolation and filtration of cell-derived vesicles according to the present invention, cell-derived vesicles can be isolated and filtered with high yield and high purity.
Inventors:
PARK JIN HEE (KR)
HUI CHONG LAU (KR)
OH SEUNG WOOK (KR)
BAE SHIN GYU (KR)
HUI CHONG LAU (KR)
OH SEUNG WOOK (KR)
BAE SHIN GYU (KR)
Application Number:
PCT/KR2021/004883
Publication Date:
November 04, 2021
Filing Date:
April 19, 2021
Export Citation:
Assignee:
MDIMUNE INC (KR)
International Classes:
C12N5/0775; B01D63/02
Foreign References:
| KR101895916B1 | 2018-09-07 | |||
| KR102008667B1 | 2019-08-08 | |||
| KR20160075692A | 2016-06-29 |
Other References:
MITJA L HEINEMANN; MATTHIAS ILMER; LESLIE P SILVA; DAVID H HAWKE; ALEJANDRO RECIO; MARIA A VORONTSOVA; ECKHARD ALT; JODY VYKOUKAL: "Benchtop isolation and characterization of functional exosomes by sequential filtration", JOURNAL OF CHROMATOGRAPHY A, vol. 1371, 1 December 2014 (2014-12-01), pages 125 - 135, XP055372708, ISSN: 0021-9673, DOI: 10.1016/j.chroma.2014.10.026
HARTING MATTHEW T., SRIVASTAVA AMIT K., ZHAORIGETU SIQIN, BAIR HENRY, PRABHAKARA KARTHIK S., TOLEDANO FURMAN NAAMA E., VYKOUKAL JO: "Inflammation-Stimulated Mesenchymal Stromal Cell-Derived Extracellular Vesicles Attenuate Inflammation : Stimulated EVs Attenuate Inflammation", STEM CELLS, vol. 36, no. 1, 1 January 2018 (2018-01-01), pages 79 - 90, XP055862538, ISSN: 1066-5099, DOI: 10.1002/stem.2730
HARTING MATTHEW T., SRIVASTAVA AMIT K., ZHAORIGETU SIQIN, BAIR HENRY, PRABHAKARA KARTHIK S., TOLEDANO FURMAN NAAMA E., VYKOUKAL JO: "Inflammation-Stimulated Mesenchymal Stromal Cell-Derived Extracellular Vesicles Attenuate Inflammation : Stimulated EVs Attenuate Inflammation", STEM CELLS, vol. 36, no. 1, 1 January 2018 (2018-01-01), pages 79 - 90, XP055862538, ISSN: 1066-5099, DOI: 10.1002/stem.2730
Attorney, Agent or Firm:
KIM, Soon Woong (KR)
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