Title:
METHOD OF FLUORINATION
Document Type and Number:
WIPO Patent Application WO/2004/050676
Kind Code:
A1
Abstract:
A method in which a glucide, examples of which include a monosaccharide, an oligosaccharide, a polysaccharide, a composite saccharide comprising any of these saccharides and a protein or lipid bonded thereto, a polyalcohol, an aldehyde, ketone, or acid of a polyalcohol, a derivative or condensate of any of these, is reacted with a fluorinating agent represented by the general formula (I) either thermally or by irradiation with microwave or an electromagnetic wave with a wavelength around the microwave region. By the method, fluorination reaction can be safely conducted position-selectively even in a temperature range of 150 to 200°C, in which fluorination has conventionally been difficult. The method in which the reactants are irradiated with microwave or an electromagnetic wave with a wavelength around the microwave region is applicable to substrates other than glucides. When a complex compound comprising HF and a base, for example, is reacted with a substrate by irradiation with microwave, fluorination in a specific position which has been difficult in conventional techniques proceeds highly selectively in a short time efficiently and safely. (I)
Inventors:
HARA SHOJI (JP)
FUKUHARA TSUYOSHI (JP)
FUKUHARA TSUYOSHI (JP)
Application Number:
PCT/JP2003/015336
Publication Date:
June 17, 2004
Filing Date:
December 01, 2003
Export Citation:
Assignee:
MITSUBISHI GAS CHEMICAL CO (JP)
HARA SHOJI (JP)
FUKUHARA TSUYOSHI (JP)
HARA SHOJI (JP)
FUKUHARA TSUYOSHI (JP)
International Classes:
C07B39/00; C07C17/093; C07C17/16; C07C17/18; C07C29/64; C07C51/60; C07C67/307; C07G99/00; C07H1/00; C07H9/04; C07H13/04; C07H13/08; C07H19/06; (IPC1-7): C07H9/04; C07H1/00; C07H13/04; C07H13/08; C07H19/06
Domestic Patent References:
| WO2003020685A1 | 2003-03-13 | |||
| WO2000058240A1 | 2000-10-05 | |||
| WO2001002320A1 | 2001-01-11 | |||
| WO1997041083A1 | 1997-11-06 |
Foreign References:
| EP1172369A1 | 2002-01-16 | |||
| US3101357A | 1963-08-20 |
Other References:
DMOWSKI W. ET AL.: "Dialkyl-alpha, alpha-difluorobenzylamines and dialkyl(trifluoromethyl)amines - novel fluorinating reagent", JOURNAL OF FLUORINE CHEMISTRY, vol. 23, no. 3, 1983, pages 219 - 228, XP002959889
THE CHEMICAL SOCIETY OF JAPAN: "Shin jikken kagaku koza 14 yuki kagobutsu no gosei to han'no [I]", 1977, MARUZEN CO. LTD., pages: 308 - 331, XP002979187
GEDYE R. ET AL.: "The use of microwave ovens for rapid organic synthesis", TETRAHEDRON LETTERS, vol. 27, no. 3, 1986, pages 279 - 282, XP002123963
See also references of EP 1568703A4
THE CHEMICAL SOCIETY OF JAPAN: "Shin jikken kagaku koza 14 yuki kagobutsu no gosei to han'no [I]", 1977, MARUZEN CO. LTD., pages: 308 - 331, XP002979187
GEDYE R. ET AL.: "The use of microwave ovens for rapid organic synthesis", TETRAHEDRON LETTERS, vol. 27, no. 3, 1986, pages 279 - 282, XP002123963
See also references of EP 1568703A4
Attorney, Agent or Firm:
Ohtani, Tamotsu (Bridgestone Toranomon Bldg. 6F. 25-2,
Toranomon 3-chom, Minato-ku Tokyo, JP)
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